107 citations
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June 1997 in “PubMed” In this study, disrupting the epidermal growth factor receptor in mice led to abnormal hair and skin development, characterized by disorganized hair follicles and systemic disease, providing a model for understanding EGFR's role in skin biology.
65 citations
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September 2014 in “BMC genomics” This research found that variations in the KRTAP gene family are likely responsible for the diverse hair phenotypes seen among mammals, influenced by gene repertoire differences, expression, and evolutionary factors.
14 citations
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December 2016 in “PloS one” This study found that Keratin 26 is expressed differently in hair follicle phases, particularly during catagen and telogen, influencing cashmere growth and interacting antagonistically with the BMP signaling pathway.
7 citations
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July 2022 in “Pharmaceuticals” This study reports that pumpkin seed oil-loaded niosomes significantly decreased hair loss and increased hair growth indicators in vivo, suggesting potential as a natural anti-hair loss therapy.
4 citations
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July 2022 in “Frontiers in Cell and Developmental Biology” This review discusses the formation and maintenance of hair follicles through dynamic cellular changes and signaling pathways, presenting a comprehensive overview but providing no new experimental findings.
3 citations
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June 2023 in “Medicines” This review identified alopecia as a significant cosmetic side effect of antiseizure medications, particularly with valproate, lamotrigine, and carbamazepine, noting that hair loss often improves after dose adjustment.
2 citations
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July 2024 in “Frontiers in Veterinary Science” In this study, researchers using a multi-omics approach identified specific proteins involved in the hair follicle cycle of Inner Mongolia Cashmere Goats, finding that API5 affects apoptosis, while ribosomal proteins are highly expressed during the resting stage, providing insights into hair follicle growth and apoptosis.
2 citations
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January 2022 in “Clinical, Cosmetic and Investigational Dermatology” This study found that a refined wash test can effectively differentiate shedding hair characteristics among normal individuals, and patients with androgenetic alopecia or telogen effluvium, aiding in diagnosis and monitoring.
2 citations
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February 2021 in “The Journal of clinical and aesthetic dermatology” This review examines the various potential causes of bitemporal hair loss, emphasizing the importance of prompt diagnosis to prevent further hair loss in scarring conditions; it reports no new clinical results.
1 citations
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May 2025 in “Maturitas” This article highlights that hormonal changes during menopause can significantly affect hair health, leading to decreased hair density, altered texture, and increased hair disorders, which may subsequently impact emotional well-being in women.
1 citations
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May 2023 in “Cutis” In this source, it is highlighted that dermatologists can identify and manage eating disorders early, potentially improving outcomes and reducing irreversible damage from malnutrition, though specific results are not reported.
January 2026 in “Current Issues in Molecular Biology” This paper reviews the emerging role of FGF-7 signaling in hair regeneration, highlighting its potential as a target for new therapies despite limited clinical trial data.
August 2025 in “Journal of Cosmetic Dermatology” This review explores low-level light therapy's potential as a noninvasive treatment for various forms of alopecia, noting its promising results in hair regrowth and density but highlighting the need for standardized protocols and further research.
August 2025 in “Aesthetic Plastic Surgery” This review explores the mechanisms, current products, challenges, and innovative approaches related to cosmetics for hair loss prevention and growth promotion, emphasizing the need for multidisciplinary cooperation to enhance product development and market success.
This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.
This study found that a combination of topical and oral treatment led to greater improvements in hair density, thickness, and anagen/telogen ratio in patients with androgenetic alopecia compared to topical treatment alone, with significant benefits observed over a 3-month period.
This literature review examined topical treatments for various alopecia types, finding that minoxidil and corticosteroids are effective for multiple conditions, while JAK inhibitors show promise specifically for alopecia areata. The study emphasized the importance of individualized therapeutic approaches to enhance outcomes in hair loss management.
October 2024 in “Frontiers in Nutrition” This study found that patients with alopecia, particularly alopecia areata and female pattern hair loss, often have vitamin D deficiency, suggesting that screening for vitamin D could benefit these patients.
August 2024 in “Nutrients” This study found that a combination of probiotic strains of Lactiplantibacillus administered over 16 weeks reduced the number and density of telogen hairs in individuals with androgenic alopecia, while increasing the abundance of Lactobacillus in their gut microbiota.
August 2024 in “EMJ Dermatology” This review addresses the causes, mechanisms, and treatment options for the most common non-scarring alopecias in females, including telogen effluvium, alopecia areata, and female pattern hair loss.
May 2024 in “BMC veterinary research” In this study, researchers observed that metabolite expression patterns, including sugars, lipids, amino acids, and nucleotides, affect hair follicle growth in cashmere goats, with feeding practices potentially influencing these cycles via hormone and vitamin levels.
April 2024 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study investigates the role of retinoic acid in regulating hair follicle stem cell homeostasis to identify new potential targets for treating androgenetic alopecia.
February 2024 in “Biomedicines” This review examines the hormonal causes of hair loss, noting how androgen excess can lead to follicle miniaturization and linking estrogen deficiency and thyroid dysfunction to common alopecia types. It further discusses hormonal treatments such as finasteride, dutasteride, and spironolactone.
December 2023 in “Animals” This study used single-cell RNA sequencing to analyze 26,573 cells from the scapular skin of yaks, identifying 11 major cell types and providing insights into the diversity and morphogenesis of hair follicle cell types through detailed maps of DP cells and dermal fibroblasts.
November 2023 in “International Journal of Women's Dermatology” In this study, female patients undergoing hormone replacement therapy showed improvements in frontal hairline appearance and increased hair plucking strength, suggesting positive effects of estradiol on hair growth while excluding age-related factors.
August 2023 in “Journal of Dermatological Treatment” This systematic review concluded that mesotherapy shows potential for improving hair growth outcomes, yet lacks standardized regimens and requires further large-scale trials to establish its efficacy and safe use.
May 2023 in “Frontiers in Endocrinology” This review article discusses recent updates on the skin manifestations associated with thyroid disease, emphasizing their role as early indicators of thyroid hormone dysregulation.
This study identified ISX9 as a novel agonist of the Wnt/β‐catenin pathway, which promoted hair regrowth in mice and may offer a therapeutic approach for alopecia.
June 2022 in “Pflügers Archiv - European Journal of Physiology” This study found that the deletion of soluble epoxide hydrolase (sEH) in mice altered the hair follicle cycle and increased hair growth through effects on hair follicle stem and matrix cells.
January 2022 in “Experimental Dermatology” Minoxidil solution and foam both increase hair growth, but the solution works better than the foam.