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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Cathepsin L is essential for normal hair growth and development.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Modern science supports the use of some Ayurvedic plants for health, as ancient practices suggested.

EGFR inhibitors often cause skin problems and other side effects, but these are usually reversible and can be managed to keep patients comfortable.

Hair loss can significantly affect a person's self-esteem and body image, especially in young people, those who value their looks highly, and women.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

The drug IPI-926 is safe at 160 mg daily and may help treat certain tumors, especially basal cell carcinoma.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

TSH is usually the only test needed to check thyroid function in primary care.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Choosing the right model order in brain connectivity analysis can affect the detection of differences between healthy individuals and those with seasonal affective disorder.

Manipulating the catagen and telogen phases of hair growth could lead to treatments for hair disorders.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.