This study aims to use a comprehensive health data set to develop a statistical model that can improve personalized and preventive health care by understanding relationships between various health parameters in individuals.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.
June 2003 in “Obstetrical & Gynecological Survey” In this study, the size of vaginal prolapse was significantly linked to preoperative vaginal length and the length of vaginal excision following the Michigan four-wall sacrospinous suspension.
January 2019 in “Advances in Environmental Biology” This article discusses the structure and function of sebaceous glands and their role in skin moisture but reports no new research findings.
February 2025 in “La Pediatria Medica e Chirurgica” In this case study, a 12-year-old boy with Cushing's Disease experienced a complex diagnostic journey; ultimately, a left-side ACTH-secreting microadenoma was identified and treated with gamma knife therapy, normalizing hypercortisolism but resulting in growth hormone deficiency.
73 citations
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May 2009 in “Proceedings of the National Academy of Sciences” This study found that disrupting the Sox21 gene in mice led to progressive hair loss and regrowth, identifying Sox21 as a key regulator of hair shaft cuticle differentiation.
10 citations
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May 2007 in “PubMed” This study found that 1% topical minoxidil significantly increased hair count and improved hair growth perception among Japanese women with androgenetic alopecia compared to placebo.
2 citations
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January 2018 in “Open journal of stomatology” This study found that trichohyalin is expressed in cancerous tongue epithelial cells, while plectin-1 expression may indicate malignancy.
January 2018 in “日本薬理学会年会要旨集 =” This study reports that in young male patients with finasteride-associated infertility, semen parameters appear reversible after discontinuing the medication.
4 citations
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February 2022 in “International Journal of Cosmetic Science” This study found that watercress extract may help treat hair loss by increasing RSPO1 secretion and decreasing DKK1 secretion, improving hair thickness and density in clinical trials.
April 2024 in “Advances in Redox Research” In this study, researchers found that polysulfides in human hair keratin contribute to hair strength and antioxidant capacity, with sulfur supplementation enhancing hair strength and cuticle structure amid oxidative stresses such as UV radiation.
February 2019 in “International Journal of Dermatology and Clinical Research” In this study, Nε-(carboxymethyl) lysine was found to weaken hair follicle morphogenesis and inhibit essential cell activities in a model simulating accumulated glycation.
January 2019 in “International Journal of Plant Animal and Environmental Sciences” This study found that a 50% ethanol extract from marine green alga Chlamydomonas sp. W80 exhibited several bioactive properties, including skin lightening and hair growth promotion effects, with potential implications for bioenergy and high-value coproducts.
October 2025 in “Plastic & Reconstructive Surgery” This study evaluated the safety and effectiveness of MNC-QQ cell therapy in five men with androgenic alopecia, reporting no adverse effects and improvements in hair growth, hair density, and quality of life over six months.
December 2019 in “The American Journal of Gastroenterology” In this study, three cases of Cronkhite-Canada syndrome revealed small bowel mucosal lesions, but these findings did not correlate with clinical symptoms or steroid treatment outcomes.
January 2019 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study reported significant improvements in female pattern hair loss through a combination therapy involving spironolactone, minoxidil, and an injectable treatment over 6 to 12 months, with 95-96% patient satisfaction and minimal complications such as slight pain and hair growth in undesirable areas.
68 citations
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April 2012 in “Digestive and Liver Disease” This study found that both Elental and 6-mercaptopurine were effective for maintaining remission in Crohn's disease, without a significant difference between them over 24 months.
21 citations
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January 2021 in “Frontiers in Pharmacology” This review examines the role of thiopurines in managing inflammatory bowel diseases like ulcerative colitis and Crohn's disease, and reports no new clinical results, emphasizing the need for more studies on thiopurine withdrawal scenarios.
21 citations
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September 2019 in “Journal of the American Academy of Dermatology” Ixekizumab effectively treats generalized pustular psoriasis.
6 citations
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October 2024 in “BMC Infectious Diseases” This study observed that COVID-19 patients in Thailand infected with the Delta variant were more likely to develop pneumonia and certain post-infection conditions, while Omicron infections were associated with milder symptoms like sore throat and congestion.
1 citations
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March 2023 in “Medicine” This case report details a patient with Satoyoshi syndrome presenting with uveitis and impending central retinal vein occlusion, a previously undocumented complication, suggesting uveitis as a potential complication of the syndrome.
June 2024 in “Journal of Drug Delivery Science and Technology” This review highlights that nanocarrier-based formulations, using both synthetic drugs and natural components, show promise in overcoming the limitations of current androgenetic alopecia treatments with modified release profiles and enhanced drug delivery, though clinical trials remain limited.
February 2025 in “BioNanoScience” 283 citations
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February 2011 in “Cell stem cell” COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.
27 citations
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November 2007 in “Genomics” This study found that mutations in type I IRS keratin genes disrupt keratin protein complexes in mice, suggesting crucial roles for these genes in proper hair coat formation.
19 citations
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July 2020 in “EBioMedicine” In this study, the researchers identified a variant in the CCHCR1 gene associated with an alopecia areata subtype characterized by impaired keratinization and autoimmune events.
16 citations
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April 2006 in “Pediatrics International” This study reported that high-dose mizoribin therapy may be effective and safe for managing steroid-dependent pediatric systemic lupus erythematosus but requires monitoring of serum uric acid levels due to potential side effects.
11 citations
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June 2024 in “Molecules” This review investigated the phytochemical variations in different medicinal parts of the plant *Alpinia zerumbet*, finding distinct chemical compositions between leaves, rhizomes, fruits, seeds, and flowers, which supports the traditional use of these parts for various medicinal purposes.
9 citations
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January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” This study reports that alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate, but resolved after dose reduction or treatment discontinuation.
6 citations
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June 2024 in “Medical Review” This review emphasized the significance of biliary fibrosis in hepatobiliary disorders, exploring its clinical manifestations, epidemiology, and cellular factors, and provided insights into current clinical trials and strategies for managing fibrosis-related cholangiopathies.