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In this study, fMRI results suggested that mechanical stimulation evoked a stronger prickle sensation comprising both pain and itch on hairy skin compared to glabrous skin.

This study estimates that approximately 230,000 tactile afferent fibers innervate the human body's skin, with varying densities across different regions correlating with spatial acuity and hair follicle density.

This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.

In this study, researchers found that the glabrous skin of the rat forelimb contains sparse Meissner corpuscles and Merkel complexes, with more slowly adapting afferents in the palm and rapidly adapting afferents in the digit extremity.

This review discusses strategies for regenerating cutaneous nerve function in burn patients and highlights the potential role of autologous skin-derived adult stem cells in improving sensory recovery, but reports no new experimental findings.

This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

This study described two cases of trichoblastomas in the tactile hair skin of aged house musk shrews, highlighting that their histological structure differs from that in humans and other animals.

This study found that Florida manatees have unique types of specialized nerve endings in their vibrissae, which assist in their sensory and manipulative functions in aquatic environments.

This study found that human C-tactile afferents respond to hair deflection, suggesting a functionally relevant anatomical relationship to hair follicles similar to that observed in mice.

This study by Moore et al. (2025) provides the first evidence linking C-tactile afferents in humans to hair follicles, showing that these nerve fibers respond to hair movement rather than skin deformation, adding complexity to the understanding of their role in emotion and touch.

This study found that upper-bulge epidermal stem cells in mouse hair follicles are specialized for nerve interactions, crucial for forming tactile sensory units, and influence touch responses via EGFL6 and αv integrin pathways.

In this study, upper-bulge epidermal stem cells in mouse hair follicles were shown to play a role in forming tactile sensory units by creating an extracellular matrix that supports nerve interactions.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.

This article contains additional supporting information available online but presents no new research findings.

This paper contains no findings, serving instead as contact information for a dermatologist with no financial conflicts of interest disclosed.

In this study, researchers identified two types of potassium channels, BK and Kv4.2, in rat Merkel cells and reported that these channels play important roles in repolarizing action potentials and maintaining resting membrane potentials, potentially influencing tactile encoding in these cells.

This study found that the vermilion border and mucosa of the monkey lip have a dense sensory innervation, which correlates with their known tactile sensitivity.

This study found that Merkel cells in dogs are most numerous in sensory receptive areas like oral mucosa and facial skin, indicating a potential role in tactile sensation.

This study in male rats identified a unique type of mechanoreceptor, the club-like ending, which responds only to touch and not to self-motion during whisking, contrasting with other receptors that show mixed selectivity.

This literature study reviews the consequences of hair loss due to chemotherapy and nursing care interventions but reports no new clinical results.

This study reports that eccrine sweat glands in mice predominantly develop on the footpads, offering a reference for skin research involving genetically engineered mice.

This study found that feather patterning is primarily self-organizing and dynamic, relying on both genetic and epigenetic controls, with implications for similar processes like fingerprints and pigmentation.

This study reports a highly sensitive MEMS silicon-hair device that mimics hair follicle functions by detecting minimal forces and moments, including electrostatic attraction and surface tension of liquids.

This study reviewed literature on the use of robotic systems in plastic and reconstructive surgery, highlighting their application in various procedures despite the predominance of descriptive case reports and a lack of comparative clinical outcomes and long-term data.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

This study found that in sheep, the microRNA oar-miR-377 regulates hair follicle development by targeting the SLC24A2 gene, and identified a genetic variation associated with wool quality, suggesting potential markers for breeding.

This review discusses the multifaceted roles of hair follicles in skin health, including potential contributions to skin neoplasias, and reports no new results.

This review discusses the role of stem cell heterogeneity and compartmentalization within the epidermis and highlights their significance as niches for neighboring cells, without reporting new experimental results.