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Alopecia areata involves complex immune and genetic factors, with potential treatment targets identified, but more research is needed.

Alopecia areata and vitiligo share immune system dysfunction but differ in specific immune responses and affected areas.

The document explains how the immune system reacts to organ transplants and the treatments used to prevent rejection.

Hair RiseTM microemulsion effectively promotes hair growth and treats hair loss better than standard treatments.

The inhibitor DPP can promote hair growth.

Notch signalling helps skin cells differentiate and prevents tumors.

Vitamin D and its receptor may help prevent skin cancer.

A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.

The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.

Skin stem cells are promising for healing wounds and skin regeneration due to their accessibility and regenerative abilities.

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

Multi-omics techniques help understand the molecular causes of androgenetic alopecia.

Plant extracts can help prevent hair loss and promote hair growth.

Hair loss in male pattern baldness is linked to changes in specific genes and proteins that affect hair growth and scalp health.

Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

Metformin, usually used for diabetes, can also help treat hair loss from alopecia areata due to its ability to reduce inflammation and stimulate new hair growth.

β-Catenin signaling is involved in brain cell growth after injury and could be a therapy target.

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.

Modifying certain signals in the body can help wounds heal without scars and regrow hair.

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Wnt/ß-catenin signaling is crucial for regulating skin stem cells and hair growth, with the right levels and timing needed for proper function.