research Dermatologic Toxicities Associated with Chronic Gamma-Secretase Inhibitor Treatment for Desmoid Tumor
Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.
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research Hes1 Regulates Anagen Initiation and Hair Follicle Regeneration Through Modulation of Hedgehog Signaling
research Medications
Understanding drug interactions, side effects, and patient-specific factors is crucial for effective dermatological care.
research Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells
Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.
research Teriflunomide in Multiple Sclerosis: An Update
Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.
research Dermatologic Adverse Events from Cancer Treatments
Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.
research Estrogen Induces VEGF Expression in Dermal Papilla Cells
Estrogen increases a growth factor in hair cells which might affect hair loss.
research Rapid Skin Repigmentation on Oral Ruxolitinib in a Patient with Coexistent Vitiligo and Alopecia Areata
A man with vitiligo and alopecia saw quick skin and hair improvement with ruxolitinib, but skin color gains were lost after stopping treatment.
research A Murine Model for Inducing and Manipulating Hair Follicle Regression: Effects of Dexamethasone and Cyclosporin A
Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.
research In Vitro Suppression of Human Lymphocyte Activity by Minoxidil
Minoxidil may help hair growth by stopping immune system attacks on hair follicles.
research Overexpression of Hypoxia-Inducible Factor-1α in Hidradenitis Suppurativa: The Link Between Deviated Immunity and Metabolism
Increased HIF-1α is linked to the inflammation and severity of hidradenitis suppurativa, suggesting treatments that lower HIF-1α could help.
research An Accessible Pharmacodynamic Transcriptional Biomarker for Notch Target Engagement
Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.
research Predictive Modeling of Patient Response to JAK/STAT Inhibitors and Dynamic Patient-Matching
Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
research A Young Girl With Lupus, Recurrent Pericardial Effusion, And Cardiac Tamponade
Adding colchicine stopped the girl's recurring heart issues caused by lupus.
research Annotated Patent Selections
The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.
research The Pharmacology of Methotrexate
Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.
research Cicatricial (Scarring) Alopecias: Comprehensive Review and Management
Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.
research Proliferative And Necrotizing Otitis Externa In Four Cats
Topical 0.1% tacrolimus significantly improved ear infections in cats.
research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles
Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.
research Non-Invasive Approaches for the Diagnosis of Autoimmune/Autoinflammatory Skin Diseases: A Focus on Psoriasis and Lupus Erythematosus
Non-invasive methods show promise for diagnosing skin diseases like psoriasis and lupus but need more research for regular use.
research Systemic Treatment for Alopecia Areata
Effective treatments for severe alopecia areata are still lacking.
research Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata
A 14-year-old girl with severe hair loss regrew her hair using upadacitinib.
research At The Crossroads Of Two Alopecias: Androgenetic Alopecia Pattern Of Hair Regrowth In Patients With Alopecia Areata Treated With Oral Janus Kinase Inhibitors
JAK inhibitors help hair regrowth but not fully effective for androgenetic alopecia.
research Correlation Between Serum Granulysin Level and Clinical Activity in Patients with Alopecia Areata Before and After Tofacitinib Therapy
Higher granulysin levels in the blood are linked to more severe hair loss in alopecia areata patients, and these levels decrease after effective treatment.
research Serum Levels of Interleukin-1 (IL-1α, IL-1β) in Patients with Alopecia Areata
IL-1α levels are higher in alopecia areata patients, suggesting a role in the disease.
research Acne-Associated Syndromes
Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.
research Small Molecule Inhibitors and Inflammatory Skin Diseases
New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.
research Main Plenary Sessions: Summaries of Papers
UK medical students lack dermatology education, liver biopsy patients with risk factors show more fibrosis, and certain fungi resist drugs due to melanin; genetics may influence female hair loss.
research Corticosteroids for the Treatment of Duchenne Muscular Dystrophy
Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.
research Melatonin: A Cutaneous Perspective on Its Production, Metabolism, and Functions
Melatonin may benefit skin health and could be a promising treatment in dermatology.