October 2024 in “Journal of Education Health and Sport” The literature review on alopecia areata (AA) examines a range of treatment options, emphasizing the importance of personalized treatment plans due to the variability in patient response. Topical therapies, particularly corticosteroids, are effective for mild cases, while systemic therapies are recommended for moderate to severe AA. Intralesional corticosteroids show promising results, with 71% of patients experiencing hair regrowth, though they may cause skin atrophy. JAK inhibitors, such as ruxolitinib and tofacitinib, demonstrate potential but often lead to relapse after treatment. Combination therapies, including diphenylcyclopropenone with anthralin, are noted for their effectiveness in chronic extensive cases. Despite the promise of newer treatments like JAK inhibitors and biological treatments, further large-scale studies are needed to confirm their efficacy and safety. The review highlights the psychological impact of AA and advocates for a comprehensive approach to management, including early intervention and individualized strategies.
November 2023 in “Frontiers in pharmacology” Drug repositioning offers hope for new, affordable treatments for a genetic skin disorder called ARCI.
August 2023 in “JOJ dermatology & cosmetics” Antibiotics often cause skin reactions, making them a major health concern.
February 2023 in “Research Square (Research Square)” Blocking IL-17 can reduce skin inflammation in a mouse model of pityriasis rubra pilaris.
October 2019 in “Turkderm” Patients with pernio have lower vitamin B12 and ferritin levels than healthy people.
September 2013 in “Neurodegenerative disease management” Teriflunomide is effective and generally safe for treating relapsing multiple sclerosis, reducing relapse rates and disability progression.
January 2012 in “Methods in pharmacology and toxicology” TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.
19 citations,
August 2017 in “American journal of clinical dermatology” Hepatitis B virus exposure may be linked to increased risk of alopecia areata.
22 citations,
December 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” A mouse gene mutation increases the risk of skin cancer.
1 citations,
July 2023 in “Journal of Clinical Medicine” Different causes of beard hair loss have various treatments, including medications, lifestyle changes, and procedures to stimulate hair growth.
June 2024 in “Frontiers in immunology” Sequential therapy with dupilumab and baricitinib improved hair regrowth and atopic dermatitis in a child without adverse reactions.
August 2023 in “Skin Research and Technology” BLH308, with persimmon leaf, green tea, and sophora fruit extracts, safely increased hair density and thickness.
19 citations,
July 2020 in “EBioMedicine” A gene variant increases the risk of a type of hair loss by affecting hair protein production.
2 citations,
September 2018 in “JAAD case reports” A rare type of skin cancer with mucosal involvement was partially treated but eventually relapsed.
1 citations,
January 2020 in “Journal of Feline Medicine and Surgery Open Reports” Ciclosporin A effectively treated a cat's severe skin condition.
9 citations,
June 2023 in “Cells” Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.
August 2024 in “Nature Communications” Softer hydrogels help wounds heal better with less scarring.
110 citations,
December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Alopecia areata is a genetic and immune-related hair loss condition that is often associated with other autoimmune diseases and does not typically cause permanent damage to hair follicles.
2 citations,
October 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” AIRE deficiency causes hair loss similar to alopecia areata in mice.
September 2023 in “Medicine” The research suggests immune system changes and specific gene expression may contribute to male hair loss, proposing potential new treatments.
November 2019 in “SLAS technology” New findings suggest certain genes and microRNAs are crucial for wound healing, and innovative technologies like smart bandages and apps show promise in improving treatment.
January 2013 in “Open journal of gastroenterology” Ulcerative colitis can cause skin issues due to immune system problems.
142 citations,
March 2019 in “Molecules/Molecules online/Molecules annual” Cannabinoids may help treat various skin conditions.
38 citations,
January 2017 in “PPAR Research” PPAR-γ helps control skin oil glands and inflammation, and its disruption can cause hair loss diseases.
16 citations,
October 2023 in “Molecular cancer” New treatments like nanotechnology show promise in improving skin cancer therapy.
12 citations,
November 2020 in “Transplant international” Hand and forearm transplants can be successful long-term, but they come with challenges like rejection and side effects from immunosuppression.
8 citations,
February 2022 in “Vascular Health and Risk Management” Some skin conditions may increase the risk of heart disease, and understanding their connection could lead to better treatments.
2 citations,
September 2022 in “Cytotherapy” Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.
August 2023 in “Dermatology and Therapy” Imiquimod can cause rare skin side effects, some irreversible, and long-term follow-up is important for users.
January 2017 in “Journal of Investigative Dermatology Symposium Proceedings” The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.