Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that frontal fibrosing alopecia is a highly inflammatory disease involving TH1 and JAK-STAT pathways, without reduced hair keratins, highlighting JAK-STAT signaling as a potential therapeutic target.

This study identified novel compound heterozygous mutations in the hairless gene among a non-consanguineous Chinese family with congenital atrichia, illustrating phenotypic variations due to founder or modifier genes.

This case report describes a Japanese man with severe COVID-19 who regained independence and returned to work after undergoing rehabilitation therapy, highlighting its potential benefits for recovery.

This study found that certain gene polymorphisms in keratin 27 and ELOVL4 are linked to improved cashmere fineness and production traits in Liaoning cashmere goats.

This study found that PNU 157706 is a highly potent inhibitor of human 5α-reductase enzymes, showing a stronger and longer-lasting antiprostatic effect in rats compared to finasteride.

In this study, FCE 28260 showed greater potency than finasteride in inhibiting 5α-reductase enzymes and reducing prostate DHT levels in rats.

This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

This study found that hair follicle stem cells, when transplanted in a rat model of ischaemic stroke, migrated to affected areas, expressed neuron-specific markers, and reduced infarct volume, suggesting potential therapeutic benefits.

This study found that kaempferol increased the proliferation potential of basal epidermal cells in three-dimensional skin models by enhancing integrin expression and altering cell morphology.

This study found that elevated STAT5 levels are linked to improved hair-inducing capabilities in human dermal papilla cells, and reducing STAT5 impairs hair follicle induction.

This study found that treating human dermal fibroblast cells with ginsenoside Rd increased the expression of mRNA associated with the dermal-epidermal junction, suggesting potential as an anti-aging cosmetic ingredient.

This study found that TGFbeta is a key pathway causing age-related loss of dermal fat's antimicrobial function, suggesting that targeting TGFBR might help restore skin defense against infections in older age.

This study found that the absence of Hes1 in hair follicles delays secondary hair germ activation and shortens the anagen phase, impacting HFSC self-renewal and long-term hair regeneration.

This study found that chitosan and surface-deacetylated chitin nanofibrils promoted hair growth in mice and increased fibroblast growth factor-7 production in human follicle dermal papilla cells.

This review discusses the role of the TOR pathway in aging and suggests that rapamycin could potentially target age-related diseases, but reports no new clinical results.

This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.

This study found that anagen-phase hair follicles in mice are particularly sensitive to damage by ruby laser pulses, resulting in alopecia without scarring, suggesting enhanced laser hair removal strategies.

This study found that stimulating the olfactory receptor OR2AT4 in human hair follicles with a synthetic sandalwood odorant promotes hair growth ex vivo by decreasing apoptosis and increasing IGF-1 production.

This study found that sympathetic nerves and arrector pili muscles form a niche that modulates hair follicle stem cell activity, revealing their role in hair follicle regeneration.

This study found that mutations in phosphorylation sites on the PIN3 protein disrupt its phosphorylation and subcellular trafficking, affecting auxin transport and root growth in a cell-type-specific manner.

In this study, hair damaged by permanent dye showed signs of recovery over time, with near complete restoration to its original state after eight weeks.

In this study, three children with severe alopecia treated with systemic tofacitinib showed significant hair regrowth, suggesting it may be a potential option for those unresponsive to conventional therapy.

This study reports that a sarcoptic mange outbreak, likely originating from mange-infected llamas from a governmental program, dramatically reduced vicuña and guanaco populations in San Guillermo National Park, Argentina.

This review discusses the design and advances of lipid–polymer hybrid nanoparticles as promising delivery systems for genome editing strategies, highlighting their potential in biomedical applications.

This study found that in Alcorcón, Spain, migrants from Sub-Saharan Africa, the Caribbean, and Latin-America had a higher risk of COVID-19 infection during the first wave compared to Spaniards.

This study characterized the SARM PF-05314882, finding it demonstrates anabolic activity in rats with minimal effects on the prostate, seminal vesicles, and luteinizing hormone levels.

This research examined the transcriptional landscape of quiescent melanocyte stem cells (qMcSCs) in adult female mice, revealing significant heterogeneity within this cell population and identifying novel subpopulations that vary in immune privilege regulation, melanocyte differentiation potential, and neural crest potential.

In this study, researchers used embryonic chicken skin as a model to show that perturbing calcium signaling can induce feather bud formation in areas that typically do not form them, highlighting developmental bioelectricity as a crucial yet underexplored layer in tissue patterning.

This study found that human dermal stem/progenitor cells demonstrated greater proliferation and differentiation potential than hair follicle dermal papilla cells, which showed increased expression of hair regeneration markers.

This study found that ethinylestradiol and high-dose cyproterone acetate significantly reduced hirsutism scores and were effective for treating acne and alopecia in women with hyperandrogenism.