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Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.

Mesenchymal stem cell therapy may help treat alopecia areata by promoting hair growth and reducing inflammation.

MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Fat from the body can help improve hair growth and scars when used in skin treatments.

RANK-RANKL signaling is essential for hair growth and skin health.

Lymphatic vessels are essential for hair follicle growth and skin regeneration.

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

CDP is crucial for lung and hair follicle cell development.

Too much β-catenin activity can mess up the development of mammary glands and make them more like hair follicles.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Drosha and Dicer are essential for hair follicle health and preventing DNA damage in skin cells.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.

Advanced therapies like gene, cell, and tissue engineering show promise for hair regrowth in alopecia, but their safety and effectiveness need more verification.

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

Women with PCOS have fewer activated T cells in their ovarian follicles, which might affect fertility.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

Recombinant keratin materials may better promote skin cell differentiation than natural keratin.

CD4+ skin cells may be precursors to basal cell carcinoma.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.