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This study found that acne tarda is prevalent, particularly among women and individuals with darker skin, with hormonal imbalances and endocrine disorders like PCOS commonly associated with its pathogenesis.

This review synthesizes information on isotretinoin’s systemic toxicity, emphasizing that its adverse effects, including mucocutaneous, hepatic, and musculoskeletal reactions, primarily reflect its pharmacodynamic actions and are generally manageable with individualized dosing and monitoring, though its teratogenicity remains a significant safety concern.

This review discusses various treatments for moderate-to-severe acne, highlighting antibiotics, oral isotretinoin, and hormonal therapies, with a focus on resistance and emerging treatment options but reports no new clinical results.

This review discusses isotretinoin's effectiveness against severe acne vulgaris and its associated side effects, including teratogenicity and hair loss, but it reports no new experimental results.

This pharmacovigilance study found that certain systemic medications, including finasteride, bortezomib, and dupilumab, were disproportionately reported in association with eyelid disorders like blepharitis, meibomian gland dysfunction, and chalazia, suggesting these drugs may contribute to these conditions though benefits might still outweigh the risks.

In this review study, systemic isotretinoin emerged as the most effective treatment for dissecting cellulitis of the scalp, while biologics and JAK inhibitors showed promise for resistant cases, and procedural methods were used in severe stages; however, controlled studies are needed for developing clinical guidelines.

This article discusses the association of acne with various systemic diseases, emphasizing the role of androgen steroids, insulin resistance, and inflammation in acne pathogenesis, but it reports no new clinical results.

This study describes the efficacy of oral isotretinoin in treating severe, hormonal, and treatment-resistant acne, noting significant side effects that depend on dose and duration, including teratogenic risks and common issues like skin dryness, while underscoring the importance of systematic monitoring to mitigate adverse effects.

The EADV Task Force on Hair Diseases reviewed existing literature and clinical experience to propose diagnostic and therapeutic recommendations for managing folliculitis decalvans, highlighting oral antibiotics, glucocorticosteroids, isotretinoin, and various systemic and topical therapies as key options for managing inflammation and preventing further hair loss.

This study reported that acne was the most common reason for admission to a dermatology clinic in Turkey during the peak of the COVID-19 pandemic, with many patients seeking systemic isotretinoin prescriptions.

In this study, a unique form of chronic superficial pyoderma gangrenosum with verrucous and ulcerative lesions was reported to heal without systemic corticosteroids in most patients.

The woman's skin and hair symptoms were confirmed as frontal fibrosing alopecia, and while facial papules are common in such cases, there's no effective local treatment, but systemic treatments can help.

This source describes clascoterone, a new topical treatment for acne vulgaris that blocks androgen receptors to reduce sebaceous gland activity and inflammation, offering a lower risk of systemic side effects compared to oral treatments.

This study reviewed cases of Graham–Little-Piccardi–Lassueur syndrome and found that topical treatments were generally ineffective, while systemic therapies like prednisone, hydroxychloroquine, and isotretinoin led to partial hair regrowth and disease stabilization, highlighting the importance of early diagnosis and systemic therapy to improve outcomes.

This review outlines the complex factors involved in acne pathogenesis—including hormonal, genetic, and environmental influences—and describes current comprehensive management strategies, emphasizing both topical and systemic therapies, while also highlighting emerging treatment options and the significant psychological impact of acne.

This review discusses treatments for frontal fibrosing alopecia and lichen planopilaris, noting that systemic 5-alpha reductase inhibitors are most effective for stabilization and potential hair regrowth, but reports no new clinical results.

This paper reviews the diverse skin, nail, and hair changes caused by medications, highlighting hyperpigmentation, alopecia, and nail structural alterations, but reports no new data.

This study found that isotretinoin treatment significantly increased p53 expression in the skin of acne patients, inversely correlating with acne severity and body mass index.

This study found that isotretinoin treatment significantly increased p53 expression in the skin of acne vulgaris patients, which may help explain its effects on sebum production and adverse effects.

This study found that isotretinoin is a safe and well-tolerated acne treatment, with common adverse effects like cheilitis manageable through symptomatic medication and no significant changes in lipid or liver enzyme levels.

Papular mucinosis can cause eyebrow hair loss, but treatment can lead to regrowth.

In this study, experts propose a diagnostic and treatment guideline for folliculitis decalvans, emphasizing the role of trichoscopy and introducing a therapeutic algorithm tailored to disease activity, which is significant for clinical management given the lack of specific clinical trials.

This review synthesizes current evidence on therapies for dissecting cellulitis of the scalp, noting that biologics show promise for treatment-resistant cases, though systemic retinoids remain the first-line therapy.

This study provided 18 evidence-based recommendations for managing acne vulgaris, strongly endorsing treatments like benzoyl peroxide, topical retinoids, and oral isotretinoin for severe cases, and issued conditional recommendations for therapies like salicylic acid and spironolactone, while offering good practice statements on combining treatment methods.

This case report describes a rare presentation of nevus comedonicus following the lines of Blaschko, treated with oral isotretinoin and other therapeutic measures, resulting in a reduction of episodic painful cystic lesions.

This article reviews different generations of synthetic retinoids for dermatological use, discussing their efficacy and significant side effects, but reports no new clinical results.

Prednisone has risks for lupus patients, isotretinoin is safe for mental health, transplant patients risk skin cancer, and various treatments are effective for specific skin conditions.

This review discusses psychological impacts associated with facial acne, noting that high levels of anxiety and depression among these patients are not linked to oxidative stress, and reports no new clinical results.

This case report highlights a 21-year-old man with severe nodulocystic acne resistant to conventional treatments, who showed moderate improvement with isotretinoin, and discusses its potential link to congenital digital abnormalities and Apert syndrome.

This case report discusses a 15-year-old boy with pachyonychia congenita, identifying a keratin 17 gene mutation, and highlights the need for a national registry and more accessible genetic testing in India.