Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review discusses the impact of immune-modifying therapies on COVID-19 vaccine responses, noting that a complete vaccine course can improve initially inadequate humoral responses among treated individuals compared to a single dose.

This study reports that in systemic sclerosis, CD34+ dermal fibroblasts transition to CD34−, podoplanin+, and CD90+ fibroblasts across the dermis, suggesting a role in unchecked fibrosis.

This retrospective study found a variety of dermatological adverse events associated with antineoplastic treatments, often leading to changes or suspension of cancer therapies in affected patients.

This review article connects key systemic lupus erythematosus pathobiology with current therapies, emphasizes clinical strategies for managing comorbidities, and stresses multidisciplinary care, but it reports no new clinical findings.

This study suggests that macrophages, particularly CD206⁺ macrophages, play a crucial role in squaric acid dibutylester-induced hair growth in alopecia areata treatment.

This review examines the interaction between the extracellular matrix and immune cells in skin diseases and evaluates advanced therapies that target involved molecular mechanisms, reporting no new clinical findings.

This study found that certain lncRNA gene polymorphisms in HOTAIR and MALAT1 are associated with increased susceptibility to systemic lupus erythematosus, potentially informing clinical applications.

This review highlights the role of chronic stress, oxidative stress, and immune processes in the development of Hashimoto’s thyroiditis and polycystic ovary syndrome, emphasizing the potential of antioxidants in their treatment based on the existing literature.

This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.

This study found that ischemia-modified albumin (IMA) may be a promising biomarker of oxidative stress in patients with alopecia areata, offering better potential compared to other oxidative stress markers.

This study found that PEGylated Ag₂S-ZnS@TGA-AA heteronanostructures, activated by light exposure, showed synergistic antibacterial effects against multidrug-resistant bacteria, significantly accelerating the healing of MRSA-infected wounds in comparison to untreated wounds.

This case report describes a cat suspected of experiencing systemic vasculitis as an idiosyncratic hypersensitivity reaction to fenbendazole, marking it as the first documented case in cats of this rare adverse reaction.

This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.

This review highlights that nano-antioxidants show promise as a treatment strategy for immune-mediated inflammatory diseases, like autoimmune and chronic inflammatory conditions, due to their improved stability and targeted delivery, but notes that further research is necessary to optimize their use and assess long-term safety.

This study highlights the role of immune dysregulation, microRNA modulation, and SIRT1 pathways in alopecia areata, suggesting antisense oligonucleotides targeting miR-485-3p as a promising therapeutic strategy for promoting hair regrowth and reducing inflammation in murine models.

In this case study, a 25-year-old presented with symptoms of lupus but tested negative for antinuclear antibodies, complicating diagnosis. The researchers emphasize that comprehensive diagnostic approaches, beyond ANA testing, are vital for effectively identifying and treating lupus nephritis to avoid serious outcomes.

This review discusses immune pathways involved in alopecia areata and explores emerging, more targeted therapeutic strategies, noting their potential for better safety and effectiveness compared to traditional immune suppressants.

This review examines the literature on autoimmune hair loss disorders, highlighting the collapse of immune privilege and the potential role of neurogenic stress in this process, but reports no new clinical results.

This review explores the immunological aspects of epidermal differentiation in loricrin knockout mice, offering insights into keratinization and potential intrinsic factors affecting immune function, but provides no new clinical findings.

This study found that a single instance of acute skin stretching can enhance immune surveillance and improve vaccine delivery by increasing skin permeability and promoting immune cell recruitment without causing tissue damage.

This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.

This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.

Alopecia areata is caused by an immune response, and targeting immune cells might help treat it.

This review explores the potential impact of nutrition on immune-mediated inflammatory skin diseases and evaluates whether dietary changes could help in treatment planning, but it presents no new clinical outcomes.

This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.

This study found that serum ischemia-modified albumin levels were significantly higher in patients with telogen effluvium compared to healthy controls, suggesting a potential role of oxidative stress in the condition's pathogenesis.

In this review, the researchers highlight the role of fibroblasts in regulating the extracellular matrix and immune responses, emphasizing the impact on macrophages and potential therapeutic insights for fibrotic diseases and cancer.

In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

This study found that SPARC-overexpressing adipose-derived mesenchymal stem cells significantly improved various aspects of skin wound healing in dogs, including re-epithelialization, collagen deposition, and angiogenesis, showing promise for enhancing treatment effectiveness under different physiological and pathological conditions.