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The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Itraconazole is potentially effective for treating invasive aspergillosis, but more research is needed.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Niosomes improve minoxidil skin delivery for hair loss treatment.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Chitin and chitosan are useful in cosmetics for oral care, haircare, and skincare, including UV protection and strength improvement.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

Iron deficiency may be related to hair loss, but there's not enough evidence to recommend iron screening or supplements for all hair loss patients.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Certain inhibitors slow down plant growth by causing early cell specialization without changing the cell development pattern.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Accurate diagnosis and effective oral treatment are key to managing tinea capitis and preventing its spread.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

PEVs improve minoxidil skin penetration, increasing hair growth.

Oxidative stress contributes to hair graying and loss as we age.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Terbinafine quickly builds up in skin and hair, staying effective for over 3 weeks.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.