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RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Advancements in nanoformulations for CRISPR-Cas9 genome editing can respond to specific triggers for controlled gene editing, showing promise in treating incurable diseases, but challenges like precision and system design complexity still need to be addressed.

The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.

Organic and biogenic nanocarriers can improve drug delivery but face challenges like consistency and safety.

Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.

White blood cells and their traps can slow down the process of new hair growth after a wound.

Beetroot extract nanogel may help treat hair loss caused by testosterone.

Non-classical 21 hydroxylase deficiency is an underdiagnosed cause of female hair loss and polycystic ovarian syndrome.

Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.

Spironolactone nano-formulations show promise for treating skin disorders, but more research is needed for safety and effectiveness.

Polymeric microneedles offer a less invasive, long-lasting drug delivery method that improves patient compliance and reduces side effects.

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

Immune cells are essential for skin regeneration using biomaterial scaffolds.

Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

Melatonin helps hair grow by activating the RORα receptor in goats.

The document concludes that using stem cells to regenerate hair follicles could be a promising treatment for hair loss, but there are still challenges to overcome before it can be used clinically.

Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

Advancements in tissue engineering show promise for hair follicle regeneration to treat hair loss.

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

Double-stranded RNA helps regenerate hair follicles by increasing retinoic acid production and signaling.

UVB exposure increases skin proteins for retinoic acid synthesis and shifts their location, possibly affecting skin repair.

Vitamin A affects hair loss and immune response in alopecia areata.

Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.

Cold atmospheric plasma may speed up wound healing and control infections.

Activating the Sonic hedgehog pathway can help regenerate hair follicles during wound healing in mice, potentially improving regeneration after injury.

Combining platelet-rich plasma injections and gel may effectively treat morphea, improving skin elasticity and reducing pain.

Wnt-signaling is regulated differently in skin cells and immune responses during wound healing.

New alopecia treatments aim for better results and fewer side effects.

Western diet may cause male pattern baldness; low glycemic diet with magnesium could help.