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A woman with a specific mutation causing adrenal gland issues faced fertility problems, but careful hormone therapy helped her manage it successfully.

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Topical glucocorticoids thin the skin and change collagen structure.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Glioblastoma cells can make androgens, which might help the tumor grow.

Blocking 11β-HSD1 can lessen the harmful effects of glucocorticoids on hair growth cells.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Prairie dogs with fewer neighbors are more stressed but their number of babies isn't affected.

Testosterone and its metabolites affect brain functions and could help treat neurological disorders.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.

A patient produced cortisol after adrenalectomy, possibly due to residual tissue or other body parts making steroids.

SAHA syndrome is a condition in women involving skin and hair issues, often related to hormonal imbalances, and is treated based on the underlying cause.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

Androgenetic alopecia linked to COVID-19 severity; drugs reducing androgen receptor activation may help.

The document concludes that managing non-classical congenital adrenal hyperplasia in females requires personalized treatment, genetic counseling, and a team of specialists.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Women with congenital adrenal hyperplasia have lower fertility, but with proper treatment, they can conceive successfully.

Eosinophilia-myalgia syndrome, linked to contaminated L-tryptophan supplements, caused severe symptoms and some deaths, with long-term effects in survivors.

Women with non-classic congenital adrenal hyperplasia have higher risk for heart and metabolic problems.

Skin problems are common in Lupus patients and can indicate the disease's severity, requiring specific treatments and lifestyle changes.

The document concluded that various dermatological treatments have different effectiveness and side effects, with some causing irritation, allergic reactions, or systemic effects.

Acne is linked to inflammation and insulin resistance, and is associated with various syndromes that require different treatments.

Norethisterone (jenapharm) therapy is effective for endometrial cancer.

Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.