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540-570 / 1000+ resultsresearch Role of BK channels and Kv4.2 channels in the electrophysiological properties of Merkel cells in rat whisker hair follicles
In this study, researchers identified two types of potassium channels, BK and Kv4.2, in rat Merkel cells and reported that these channels play important roles in repolarizing action potentials and maintaining resting membrane potentials, potentially influencing tactile encoding in these cells.
research Keratin Biomaterials Activate Schwann Cells via Integrin‐Mediated Signaling and Promote Regeneration of Large Peripheral Nerve Defects in a Rabbit Model
This study demonstrated that a keratin gel promotes nerve regeneration across critical defects in rabbit models, showing improved nerve conduction and muscle action potential compared to control treatments.
research The effects of sodium metasilicate on the spinal motoneuron recovery following sciatic nerve injury
This article discusses how recent research suggests that aggressive video games have little effect on aggression and violence among players, calling for professional organizations to update their policy statements accordingly.
research Decision letter: The signaling lipid sphingosine 1-phosphate regulates mechanical pain
In this study, researchers found that the bioactive lipid sphingosine 1-phosphate and its receptor, S1PR3, are essential for regulating mechanical pain sensitivity in mice.
research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
research ADVERSE EFFECTS OF OPIOID ANALGESIC DRUGS
This article discusses the long-standing use and safety of opioids in anaesthesia, noting that respiratory depression is a manageable side effect due to the availability of opioid antagonists.
research Molecular basis of hair cell loss
This review explores the mechanisms of hair cell death due to factors like noise, ototoxic drugs, and aging and reports no conclusive clinical results; ongoing research may eventually enable preventive treatments for hearing loss.
research Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity
research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
This study provides the first crystal structure of the human SRD5A2 enzyme, revealing key insights into its function and inhibition which may aid future drug development.
research Post-finasteride syndrome – does it really exist?
This article discusses post-finasteride syndrome as a distinct syndrome related to prolonged use of 5α-steroid reductase inhibitors, noting persistent side effects even after discontinuation and no new research results are reported.
research The Charnoly body as a universal biomarker of cell injury
This review discusses Charnoly bodies as biomarkers of cell injury and potential therapeutic targets in neurodegenerative, cardiovascular, and cancer treatments but reports no new clinical results.
research TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice
This study found that etifoxine pretreatment reduced neuroinflammation and improved cognitive function in LPS-induced neuroinflammation in mice, potentially through increased neurosteroid synthesis and reduced apoptosis.
research Hair cell toxicology: With the help of a little fish
This review discusses the use of zebrafish larvae as an alternative model for studying ototoxicity, facilitating large-scale screening for otoprotective compounds, but reports no new clinical results.
research 5α‐reductase inhibitors: Evaluation of their potential confounding effect on GC‐C‐IRMS doping analysis
This study found that chronic administration of finasteride affected the isotopic composition of testosterone and nandrolone metabolites, impacting the drug-testing outcomes in athletic contexts.
research Pseudo "fringe sign" in frontal fibrosing alopecia
This article discusses the DOAJ, a comprehensive index of international open access journals, and emphasizes its role in providing free quality content online without presenting new research findings.
research Selected Abstracts
This study suggests that a specific region upstream of the TGF-β1 gene may play a key role in androgenetic alopecia by regulating gene expression in a cell-specific manner.
research Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice
This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.
research Combination of media, biomaterials and extracellular matrix proteins to enhance the differentiation of neural stem/precursor cells into neurons
This study observed that NSPC predominantly differentiated into neurons when exposed to serum fractions with molecules under 100 kDa, particularly with biomaterial and fibronectin, in the presence of basic fibroblast growth factor.
research 1442 Neurotransmitter signaling specify sweat gland stem cell fate through intracellular calcium regulation
This review evaluates controlled studies on Platelet-Rich Plasma for androgenetic alopecia treatment, reporting positive effects on hair growth and density but highlighting the need for standardized protocols.
research Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice
research Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice
This study found that restoring hypothalamic NPY levels in mice delayed aging-related characteristics such as fat loss, hair loss, and memory decline, suggesting that maintaining these levels could be important for counteracting aging and its effects.
research ς1Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward
This study found that neuroactive steroids like DHEA and pregnenolone influence cocaine-induced appetence in mice through their interaction with the ς1 receptor, suggesting a role in individual vulnerability to addiction.
research Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation
This study found that Sox9 plays a critical role in maintaining radial glial progenitor cells and regulates the timing of their generation of upper-layer cortical neurons.
research Mechanisms of proton inhibition and sensitization of the cation channel TRPV3
This study found that acid regulation of the TRPV3 channel can inhibit its function from outside the cell while facilitating it from inside, providing insights into skin barrier and disorder mechanisms related to tissue acidosis.
research KC DUBE AWARD
This study found that precision 40Hz gamma-transcranial alternating current stimulation significantly improved negative and cognitive symptoms in patients with schizophrenia compared to a sham group, suggesting promising potential for this neuromodulation technique in treating these symptoms.
research Innervated Biomaterials for Improved Cutaneous Wound Healing: A Review of Recent Advancements and Future Prospects
This review examines emerging biomaterial strategies designed to support both neural regeneration and cutaneous wound healing, emphasizing their potential to improve sensory function through mechanisms like axonal regrowth and vascular network formation, while noting the need for standardized assessments and clinically translatable designs.
research Nestin-Expressing Hair Follicle-Accessible Pluripotent Stem Cells for Nerve and Spinal Cord Repair
This study reports that hair follicle stem cells, termed HAP stem cells, can differentiate into neuronal and glial cells, enhancing nerve repair and locomotor recovery after injury.
research Characterizing enteric neurons in dopamine transporter (DAT)‐Cre reporter mice reveals dopaminergic subtypes with dual‐transmitter content
This study, using a reporter mouse line, characterized diverse subtypes of dopaminergic neurons in the enteric nervous system, identifying unique subtypes with potential roles in gut function and disease.
research Sensations Evoked by Microstimulation of Single Mechanoreceptive Afferents Innervating the Human Face and Mouth
This study observed that electrical stimulation of specific mechanoreceptive afferents in the orofacial region can evoke sensations consistent with their response properties, while others may require multiple afferents to access perceptual levels.