52 citations
,
February 2006 in “Current pharmaceutical design” This review discusses the use of 5α-reductase inhibitors in treating benign prostatic hyperplasia, highlighting their long-term effectiveness and benefits when combined with α1-adrenergic antagonists; it reports no new clinical results.
50 citations
,
May 2019 in “Drugs” This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.
48 citations
,
January 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified chemokine receptor ligands cxcl10 and cxcl11 as new hair-specific transcriptional targets of the Eda pathway, suggesting chemokine signaling plays a role in primary hair follicle patterning.
45 citations
,
May 2019 in “Scientific Reports” This study reported that a low color temperature light (1900 K) may have positive effects on melatonin secretion, eye protection, wound healing, and hair regeneration compared to higher temperature lights.
45 citations
,
February 2018 in “Journal of basic and clinical physiology and pharmacology/Journal of basic & clinical physiology & pharmacology” This review summarizes the ethno-medicinal uses, phytochemical constituents, and biological activities of Acorus calamus, highlighting its potential therapeutic benefits and the importance of further scientific work on this plant.
42 citations
,
September 2017 in “Advances in protein chemistry and structural biology” This chapter reviews surface plasmon resonance (SPR) methodology and its applications in basic science and human disease without reporting new clinical results.
40 citations
,
December 2019 in “Neurobiology of Stress” This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.
39 citations
,
April 2020 in “IntechOpen eBooks” The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.
39 citations
,
October 2015 in “Case Reports” In this case series, four adults developed severe, disabling multisymptom illness potentially linked to fluoroquinolone use, which persisted and progressed even after discontinuation of the drug.
38 citations
,
February 2016 in “Surgery Journal” This article discusses a wide range of procedures in facial plastic surgery and highlights the recent advancements and trends without reporting new clinical findings.
37 citations
,
January 2019 in “Food science & nutrition” This review summarizes various effects of bergamot components on multiple health conditions in humans and animals but reports limitations in their use for stress and anxiety relief in aromatherapy.
36 citations
,
April 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This article reviews the role of vasoactive intestinal peptide in maintaining immune privilege in hair follicles and does not report new findings; the authors propose it as essential for immune homeostasis in alopecia areata.
35 citations
,
June 2018 in “Urology” This study of FAERS data suggests that finasteride, particularly at the 1 mg dosage, is associated with a wide range of adverse effects not previously established in long-term studies, especially among younger men.
34 citations
,
April 2018 in “EMBO journal” This study found that in mouse skin, the activation of stem/progenitor cells is synchronized across different niches during growth, with the glutamate transporter SLC1A3 playing a crucial role in this process.
34 citations
,
June 2011 in “Alcoholism: Clinical and Experimental Research” This study suggests that neurosteroids and compounds acting on GABA(A) receptors, like THIP, may modulate ethanol intake by influencing drinking patterns.
34 citations
,
November 2010 in “Development” In this study, epidermal Notch activation increased jagged 1 expression, leading to skin changes like thickening and blistering, with these effects inhibited when jagged 1 was absent.
32 citations
,
February 2019 in “Journal of neurochemistry” This study found that pharmacological inhibition of sex steroid synthesis impacts pathogenic processes in traumatic brain injury in a sex-specific manner, with distinct effects of letrozole and finasteride on molecular and neurological outcomes.
32 citations
,
May 2010 in “Pharmacopsychiatry” This article investigates whether finasteride influences adult hippocampal neurogenesis related to depression and reports no new clinical findings; the authors suggest further research on its neurosteroid inhibition.
31 citations
,
January 2017 in “Phytotherapy Research” This review reports on the traditional and ethnopharmacological uses of Ziziphus jujuba Mills, noting its increasing global popularity for treating various ailments, but highlights that its acceptance into the European Pharmacopoeia remains unresolved due to scientific and regulatory challenges.
31 citations
,
November 2014 in “Investigative Ophthalmology & Visual Science” This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.
29 citations
,
January 2010 in “Methods in Enzymology” This review discusses five genetic fate mapping methods used to study cell behaviors during development and regeneration, detailing the necessary tools and considerations without reporting new experimental results.
26 citations
,
February 2020 in “Frontiers in genetics” This study identified three candidate genes (CORT, FGF5, and CD36) associated with cold climate adaptation in Yanbian cattle through genome resequencing and comparison with African tropical cattle.
26 citations
,
September 2018 in “Neurobiology of Disease” This study found that both finasteride and dutasteride significantly reduced L-DOPA-induced dyskinesia in a rat model of Parkinson's disease, with dutasteride showing greater effectiveness at lower doses.
26 citations
,
January 2017 in “Acta dermato-venereologica” This review examines the use of monoaminergic antidepressants for inflammatory skin disorders and reports they may reduce dermatological symptoms, suggesting a potential role beyond treating psychiatric conditions.
26 citations
,
July 2012 in “Epilepsy & Behavior” This study found that progesterone significantly delayed epileptogenesis development in a mouse model, and its effects were inhibited by finasteride, highlighting the potential role of neurosteroids in modifying epilepsy progression.
26 citations
,
February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
25 citations
,
January 2017 in “Steroids” This study found that the progesterone metabolite 3α-THP increased the proliferation and gene expression of human glioblastoma cells, suggesting a role in tumor progression.
23 citations
,
March 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that extracellular ATP released from UVB-irradiated keratinocytes promotes melanin production through the P2X7 receptor, indicating a role for ATP-P2X7 signaling in UV-induced melanogenesis.
21 citations
,
October 2018 in “European Journal of Pharmacology” This review discusses the mechanisms underlying chemotherapy-induced neuroinflammation and reports no new clinical results, emphasizing the need for a better understanding to improve management of chemotherapy side effects.
19 citations
,
July 2018 in “Medicines” This review highlights the pharmaceutical potential of secondary metabolites from Juniperus species, noting promising antitumor, antibacterial, and antiviral activities, but reports no new experimental findings.