59 citations
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March 2020 in “Journal of Biomedical Science” This study explored the complex roles of niche cells in regulating hair follicle stem cells, identifying specific cell functions such as signaling, sensing, and relaying messages, which could provide insights into treating hair loss conditions like androgenetic alopecia and alopecia areata.
1 citations
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April 2025 in “Pigment Cell & Melanoma Research” This article reviews the underlying mechanisms of segmental vitiligo with white hair, focusing on skin and hair follicle melanocytes, and proposes potential targets for treatment, highlighting neuroendocrine factors as possible contributors to the condition.
December 2025 in “Frontiers in Immunology” This review highlights that disturbances in neuroimmune communication, particularly between sympathetic nerves and macrophages, may contribute to autoimmune diseases like rheumatoid arthritis and type 1 diabetes, and suggests potential therapeutic avenues by restoring this communication in preclinical and early clinical studies.
4 citations
,
August 2021 in “Frontiers in Cell and Developmental Biology” This review discusses recent advancements in understanding how the sympathetic nervous system and norepinephrine regulate hair follicle growth, highlighting innovative studies that explore their effects on hair follicle stem cells.
March 2025 in “Molecular Medicine” This study on C57BL/6 mice found that subcutaneous cholesterol injections significantly promoted hair regeneration by enhancing hair follicle stem cell proliferation, highlighting the role of the PKA-tyrosine hydroxylase-sympathetic nervous system pathway in this process.
77 citations
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July 2020 in “Cell” This study found that sympathetic nerves and arrector pili muscles form a niche that modulates hair follicle stem cell activity, revealing their role in hair follicle regeneration.
In this study, rat vibrissa follicles transplanted into mice demonstrated survival, partial sympathetic nerve reinnervation, and increased norepinephrine levels 37 days post-implantation, suggesting potential for hair growth despite not returning to normal nerve function.
60 citations
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May 2011 in “Endocrinology and Metabolism Clinics of North America” This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.
10 citations
,
January 2014 in “Journal of prosthodontic research” This study found that while both natural and bioengineered salivary glands showed similar protein concentrations in response to taste stimulation, their protein compositions and amylase concentrations differed, which may affect nerve signal balance.
1 citations
,
October 2022 in “Annual review of cell and developmental biology” This review discusses the roles of peripheral nerves in stem cell and immune responses within the skin and hematopoietic system, emphasizing their potential in developing new therapies; it reports no new experimental results.
46 citations
,
December 2007 in “International Journal of Cardiology” This study found that patients with polycystic ovary syndrome have reduced heart rate recovery, an exaggerated systolic blood pressure response to exercise, and decreased heart rate variability, implying possible autonomic dysfunction.
This study found that acute stress can cause rapid hair loss by triggering necrosis in hair follicle cells and initiating autoimmunity, revealing a mechanism where stress-induced nerve activity leads to tissue damage and immune system activation.
5 citations
,
February 2022 in “Frontiers in physiology” This review discusses the role of various cells outside the hair follicle in regulating melanocyte stem cells and hair graying, but reports no new clinical results.
8 citations
,
January 2016 in “Cells tissues organs” This study found that chemical sympathectomy inhibited hair follicle growth in mice, suggesting that sympathetic nerves may regulate keratinocyte behavior to promote hair growth.
13 citations
,
March 2012 in “The Journal of Dermatology” This study reports that transplanted mouse hair follicles restored piloerection ability and connected properly with host tissues, suggesting potential for advanced hair restoration therapies.
1 citations
,
January 2018 in “Eastern Journal Of Medicine” In this case report, a 9-year-old girl using topical minoxidil for alopecia experienced a 6-second asystole with syncope, suggesting careful cardiac monitoring may be needed for minoxidil users.
2 citations
,
January 1980 in “Acupuncture & electro-therapeutics research” The authors suggest that male-pattern hair loss may be linked to neuropathy caused by tension on scalp nerves, potentially worsened by testosterone, and propose electrical stimulation as a temporary treatment.
February 2026 in “Journal of Integrative Neuroscience” In this study, transplantation of hair follicle stem cells and nerve growth factor-modified stem cells significantly reduced amyloid deposition and tau hyperphosphorylation in an Alzheimer's disease rat model, suggesting potential as a treatment option.
April 2015 in “Cambridge University Press eBooks” Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.
223 citations
,
December 2010 in “The Journal of Sexual Medicine” This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.
14 citations
,
January 2001 in “Primary Care Update for Ob/gyns” This review discusses the challenges in addressing female sexual dysfunction, focusing on the complexities of female sexual response, levels of dysfunction, clinical identification, and existing treatments, but presents no new clinical findings.
9 citations
,
November 2018 in “International Journal of Medical Reviews” This review discusses the prevalence and etiologies of sexual dysfunction in young men, highlighting the increased recognition of organic causes alongside psychosomatic factors, and reports no new clinical results.
2 citations
,
February 2021 in “Brain Research” This study found that testosterone replacement in castrated male rats counteracted endotoxemia-induced arterial baroreflex dysfunction without significantly affecting neuroinflammation.
1 citations
,
June 2012 in “Springer eBooks” This article discusses the potential of acupuncture as a complementary or alternative therapy for PCOS, highlighting experimental evidence of its positive effects on reproductive and metabolic function, but reports no new clinical results.
2 citations
,
January 2019 in “Springer eBooks” This review discusses segmental vitiligo as part of the vitiligo clinical spectrum and highlights its role as a model for studying repigmentation, but reports no new clinical results.
1 citations
,
February 2018 in “InTech eBooks” This paper discusses the need for comprehensive evaluation and management of lean polycystic ovary syndrome patients due to their unique risks, but reports no new results.
January 2024 in “International journal of yogic, human movement and sports sciences” This study observed that middle-aged women with Polycystic Ovary Syndrome who practiced yoga Nidra for twelve weeks experienced improvements in stress, anxiety, and depression compared to a control group that did not participate in any intervention.
437 citations
,
August 2014 in “Cell metabolism” This perspective suggests that browning agents may not directly enhance UCP1 expression in white adipose tissue but instead induce browning through increased heat loss, prompting thermogenesis to compensate.
11 citations
,
August 2014 in “Current Urology Reports” This review discusses the known effects of medications for benign prostatic hyperplasia on sexual function and mechanisms of dysfunction but reports no new clinical results.
1265 citations
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October 2013 in “The Journal of Clinical Endocrinology and Metabolism” This guideline from the Endocrine Society recommends using the Rotterdam criteria for diagnosing polycystic ovary syndrome and outlines first-line treatments, emphasizing hormonal contraceptives and lifestyle intervention.