18 citations
,
April 2001 in “Bioorganic & Medicinal Chemistry Letters” This study identified the N-(iodopropenyl) derivative 13 as a promising candidate for development as a radioiodinated androgen receptor ligand due to its binding affinity.
17 citations
,
October 2020 in “Journal of Clinical Medicine” In this study, Koreans with rosacea showed higher odds of experiencing various systemic comorbidities, including autoimmune diseases and certain cancers, compared to controls.
17 citations
,
June 2019 in “BMC genomics” This study cataloged several long non-coding RNAs and microRNAs in cashmere goat dermal papilla cells, suggesting these non-coding RNAs may play a role in hair follicle stem cell activation and hair growth.
17 citations
,
December 2015 in “Bioorganic & Medicinal Chemistry” 3-tetrazolo steroidal analogs can strongly inhibit the enzyme linked to hair loss.
17 citations
,
July 2015 in “Journal of nursing scholarship” This study found that kidney transplant recipients who experienced higher levels of symptom distress from immunosuppressive medications were more likely to be nonadherent to their medication regimen.
17 citations
,
July 2015 in “Biomolecules and Biomedicine” This study found that women with PCOS had higher levels of Nesfatin-1 and lower levels of vitamin D, which may be linked to increased blood pressure and potential hypertension.
17 citations
,
June 2012 in “European journal of medicinal chemistry” This study found that compounds 21–23 and 25 exhibited strong 5α-reductase II inhibition in vitro and significantly reduced rat prostate weight, performing comparably to finasteride.
17 citations
,
August 2007 in “Bioorganic & Medicinal Chemistry Letters” This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.
17 citations
,
May 1995 in “Anatomy and Embryology” This study found that treating neonatal mice with the neurotoxin 6-OHDA resulted in temporary hair loss and thinner skin compared to control mice, linking sympathetic neurons to hair growth and skin thickness.
16 citations
,
July 2025 in “Journal of Translational Medicine” In this study, MSC-scaffold combinations were found to significantly enhance wound closure, collagen deposition, angiogenesis, and growth factor expression while modulating inflammatory responses in preclinical burn wound models, though significant heterogeneity limits immediate clinical application.
16 citations
,
October 2024 in “Frontiers in Environmental Science” This review found that synthetic cosmetics pose risks to human health, potentially causing various diseases, and negatively impact ecosystems, air quality, and oceans from production to waste disposal, highlighting the broad environmental and health consequences of cosmetic use.
16 citations
,
January 2020 in “Annals of the rheumatic diseases” In this study, baricitinib improved the resolution of arthritis or rash in patients with systemic lupus erythematosus, but outcomes for skin involvement like alopecia were not reported.
16 citations
,
April 2016 in “Medicine” This study described a case where lupus erythematosus panniculitis preceded the diagnosis of systemic lupus erythematosus, highlighting the need for regular follow-ups in LEP patients for potential SLE development.
16 citations
,
March 2014 in “Journal of the European Academy of Dermatology and Venereology” This study found that acne was the most common dermatological manifestation in Korean women with polycystic ovary syndrome, particularly those with a specific combination of symptoms, showing distinct variations in serum hormonal and metabolic parameters.
16 citations
,
January 2014 in “International Journal of Trichology” This study found that male Indian patients under 30 with early androgenetic alopecia were more likely to have metabolic syndrome compared to age-matched controls.
16 citations
,
May 2011 in “Dermatologic therapy” This article reviews side effects and relapse rates of various systemic treatments for severe alopecia areata, reporting no new clinical findings.
16 citations
,
April 2006 in “Pediatrics International” This study reported that high-dose mizoribin therapy may be effective and safe for managing steroid-dependent pediatric systemic lupus erythematosus but requires monitoring of serum uric acid levels due to potential side effects.
16 citations
,
October 2003 in “Journal of The American Academy of Dermatology” This study describes a 4-year-old boy who exhibits a rare, synchronized pattern of hair growth and shedding, unlike the typical asynchronous pattern seen in humans.
16 citations
,
July 2002 in “Australasian Journal of Dermatology” This case report illustrates the risk of skin necrosis in patients with high antiphospholipid antibody levels after stopping anticoagulation therapy, highlighting the necessity for careful monitoring.
16 citations
,
October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology” Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
15 citations
,
September 2021 in “Journal of Clinical Medicine” This study observed that in children who unintentionally consumed high-dose oral minoxidil, 65% developed hypertrichosis, predominantly on the face, and 15% experienced mild systemic side effects.
15 citations
,
April 2016 in “Medicine” This study reports that systemic lupus erythematosus patients with Evans syndrome often exhibited photosensitivity, hypocomplementemia, and elevated serum IgG, while lupus nephritis was less common, suggesting distinct clinical features.
15 citations
,
January 2015 in “Dermatology Research and Practice” This study found no significant association between androgenetic alopecia and metabolic syndrome, though systolic blood pressure was higher in the alopecia group compared to controls.
15 citations
,
December 2011 in “Journal of the European Academy of Dermatology and Venereology” In this study, severe diffuse hair loss in patients with systemic lupus erythematosus was associated with distinct clinical, dermoscopic, and histopathological features, which improved alongside treatment of the underlying condition.
15 citations
,
October 2010 in “Archives of Toxicology” This study found that the yeast androgen screen (YAS) could detect the activity of methyltestosterone in urine for a longer period than classical GC/MS, potentially identifying long-lasting metabolites.
14 citations
,
December 2024 in “Pharmaceutics” This review examines hydrogel microneedles for transdermal drug delivery, discussing their applications and challenges but reports no new clinical results.
14 citations
,
September 2023 in “Frontiers in Nutrition” This source observed that while supplementation with pro-, pre-, and synbiotics showed some beneficial effects for PCOS-related outcomes, the evidence quality was deemed low to very low, highlighting the need for further well-designed randomized controlled trials in women with PCOS.
14 citations
,
September 2017 in “Clinical and Experimental Dermatology” In this report, a 26-year-old man with folliculitis decalvans unresponsive to standard treatments experienced significant disease clearance after 25 months of systemic photodynamic therapy, marking the first documented use of this therapy for this condition.
14 citations
,
November 2016 in “Lupus” In this retrospective study of adolescents with recalcitrant cutaneous lupus, lenalidomide treatment resulted in complete or near resolution of skin symptoms within 6 months, while allowing for a reduction in prednisone dosage.
14 citations
,
March 2016 in “Cutaneous and Ocular Toxicology” This study observed that SC users commonly exhibited dermatological findings like periorbital darkening and blade scars, highlighting the importance for dermatologists to recognize these markers for early diagnosis and intervention.