77 citations
,
August 2025 in “Signal Transduction and Targeted Therapy” This review highlights the potential of extracellular vesicle-based therapies for treating various diseases, but it also notes challenges like the lack of regulatory guidelines that hinder their clinical development.
61 citations
,
June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that liposomes coated with cationic polymers, chitosan and Eudragit EPO, showed improved physicochemical stability and enhanced skin diffusion of aciclovir and minoxidil compared to uncoated liposomes.
28 citations
,
September 2020 in “Pharmaceutics” This review discusses the potential of three-dimensional printed mesoporous scaffolds for drug delivery applications, particularly for bone cells and tissues, but reports no new clinical results.
8 citations
,
May 2023 in “Gels” This review discusses the advantages and progress of chitosan hydrogels in vascular regeneration for tissue engineering scaffolds, highlighting modifications to enhance their application and exploring future prospects.
4 citations
,
May 2025 in “Stem Cell Research & Therapy” This review explores the potential of extracellular vesicle therapy as a novel strategy to delay intervertebral disc degeneration and enhance tissue repair, by modulating key pathogenic mechanisms, with a focus on the molecular components and bioengineering modifications of extracellular vesicles.
This study observed that treating human hair with NaOH led to partially removed cuticles, resulting in better fiber cohesion and mechanical properties similar to wool, unlike bleach or formic acid treatments, which weakened the fibers.
January 2024 in “Regenerative Biomaterials” This review introduces the potential of metal-organic framework-based functional composite materials in tissue engineering but reports no new results, emphasizing the need for further innovation in the field.
193 citations
,
February 2015 in “Nature Communications” Fungi-produced compounds can change plant root growth.
61 citations
,
September 2016 in “NPG Asia Materials” This study developed thermo-reversible glycol chitosan hydrogels that effectively form and maintain 3D cell spheroids within one day, offering a simplified method for creating biologically realistic cultures for tissue regeneration and drug screening applications.
61 citations
,
October 2013 in “PLoS ONE” This study found that amplifying Wnt signaling, either genetically or through topical application of liposomal Wnt3a, improved skin wound healing in a mouse model.
59 citations
,
August 2014 in “International Journal of Biological Macromolecules” In this study, the researchers optimized the extraction conditions for crude polysaccharide from Hibiscus rosa-sinensis leaves, achieving a yield of 9.66% and demonstrated strong antioxidant activities in vitro.
52 citations
,
November 2013 in “European Journal of Pharmaceutical Sciences” This study examined different polymersome systems for topical finasteride delivery and found that chitosan-decorated C7 polymersomes may enhance skin retention and provide controlled drug release compared to non-decorated systems in laboratory settings.
34 citations
,
July 2022 in “Gels” This review explores the potential of alginate as a promising alternative to donor tissue for corneal transplantation due to its adaptability, transparency, and low immunogenicity, and discusses how chemical modifications can enhance its properties for use in corneal tissue engineering.
33 citations
,
April 2011 in “Journal of Veterinary Internal Medicine” This study found that inhaled fluticasone for 11 months did not adversely affect the immune function or response to vaccination in horses with heaves.
28 citations
,
March 2014 in “International Journal of Nanomedicine” This study developed lipid nanoparticles for delivering minoxidil and finasteride to the dermis and hair follicles, showing stability and a desired prolonged release, though with low skin penetration levels.
18 citations
,
February 2022 in “Cell Death Discovery” In this study, researchers found that hair follicle-derived mesenchymal stem cells, modified to overexpress extracellular matrix protein 1, significantly improved liver function and reduced liver damage in cirrhotic mice by inhibiting hepatic stellate cell activation and TGF-β/Smad signaling.
18 citations
,
January 2017 in “Dermatologic Surgery” This review examines intrinsic and extrinsic aging impacts and presents evidence-based lifestyle recommendations to complement cosmetic procedures for enhanced antiaging outcomes, but it reports no new clinical results.
14 citations
,
April 2017 in “Scientific Reports” This study demonstrated that using a perfusion culture bioreactor and 3D spheroid culture can enhance corneal endothelial cell expansion and support the construction of tissue-engineered corneal endothelial layers in vitro.
11 citations
,
January 2018 in “Asian Journal of Andrology” Researchers observed that dutasteride and finasteride caused structural changes in the penises of both control and hypertensive rats, with dutasteride having a more pronounced effect on the corpus cavernosum.
10 citations
,
April 2016 in “Research and reports in transdermal drug delivery” This review discusses the potential of follicular drug delivery systems to target the pilosebaceous unit and reports no new research findings.
9 citations
,
November 2018 in “Journal of cosmetic dermatology” This study reports that a plant extract from Orobanche rapum can stimulate skin rejuvenation and protect cutaneous microbiota, potentially creating healthier skin.
6 citations
,
April 2025 in “Plastic and Aesthetic Research” This review highlights that biomaterial properties can be designed to modulate macrophage activity, potentially reducing foreign body responses and enhancing tissue healing in regenerative medicine.
5 citations
,
June 2016 in “TURKDERM” This review discusses various dermatological scoring systems used to objectively assess disease severity and guide treatment decisions, reporting no new clinical results.
5 citations
,
January 2021 in “Wiadomości Lekarskie” This study developed a protocol for acellular dermal matrix manufacturing from pig skin, demonstrating effective removal of cellular components while preserving the collagen scaffold's structural organization through a series of physical and chemical treatments.
5 citations
,
September 2012 in “Springer eBooks” Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.
4 citations
,
December 2022 in “Frontiers in cell and developmental biology” This review discusses the use of zebrafish larvae as an alternative model for studying ototoxicity, facilitating large-scale screening for otoprotective compounds, but reports no new clinical results.
2 citations
,
January 1960 in “Australian Journal of Biological Sciences” The Naked gene in mice causes abnormal sebaceous glands and disrupts hair follicle organization.
1 citations
,
January 2024 in “Scientific reports (Nature Publishing Group)” This study explored using keratin extracted from human hair waste to create biodegradable bioplastic films, revealing promising potential for applications in packaging and disposable items due to their uniform surface morphology and ability to degrade with keratinophilic fungi.
1 citations
,
October 2023 in “European journal of histochemistry” This study demonstrated that treating platelet-rich plasma with ozone or procaine in vitro led to distinct changes in platelet activity, significantly enhancing the release of platelet-derived factors without damaging the platelets, indicating potential for improved regenerative therapies.
1 citations
,
January 2022 in “Brazilian Journal of Pharmaceutical Sciences” This study investigated the physicochemical properties of polystyrene-b-poly(acrylic acid) nanovesicles coated with modified chitosans, finding that they can effectively control surface charge and potentially serve as drug delivery carriers with a 50.7% encapsulation efficiency for minoxidil.