January 2009 in “Hair transplant forum international” This article involves an interview with dermatologist Rodney Sinclair and provides no new research findings.
166 citations
,
November 2008 in “Expert Review of Endocrinology & Metabolism” This review discusses biotin and biotinidase deficiencies, their symptoms, and methods of medical management, without presenting new clinical findings.
126 citations
,
November 1987 in “The Journal of Pediatrics” This study reports that selenium deficiency in children on long-term total parenteral nutrition may lead to symptoms like erythrocyte macrocytosis and skin and hair depigmentation, which improved with selenium supplementation.
91 citations
,
May 2023 in “Journal of Cutaneous Medicine and Surgery” Alopecia Areata affects 2% globally, with treatments like essential oils, garlic, and JAK inhibitors showing promise, but more research is needed.
83 citations
,
November 2002 in “British Journal of Dermatology” This study found no direct relationship between low serum ferritin and chronic diffuse telogen hair loss in women, questioning the usefulness of serum ferritin measurement and iron supplementation for managing this condition.
76 citations
,
July 2011 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses clinical methods for diagnosing alopecia and examines current treatments for both cicatricial and noncicatricial forms but provides no new clinical results.
73 citations
,
October 2001 in “Epilepsia” In this study, valproic acid treatment was associated with reduced biotinidase activity and improved skin lesions after biotin supplementation in children with seizures.
70 citations
,
March 1980 in “Journal of Nutrition” Zinc deficiency in monkeys causes skin issues and reproductive problems, but supplementation reverses these effects.
68 citations
,
February 1996 in “Obesity Surgery” This study found that significant hair loss in about one-third of patients after vertical gastroplasty was reversed by zinc supplementation.
67 citations
,
July 2011 in “Clinical, cosmetic and investigational dermatology” This review discusses various therapeutic agents for alopecia areata, categorized by efficacy and safety, and highlights the lack of curative treatments and long-term outcome studies.
64 citations
,
March 2021 in “Anaesthesia” This review discusses the history and impact of iron deficiency anemia in women, highlighting its prevalence and the need for better detection and care, especially for those undergoing anesthesia.
60 citations
,
February 2003 in “Postgraduate Medical Journal” In this report, it was noted that severe paresthesia, ophthalmoplegia, cerebellar and extrapyramidal signs, and alopecia can strongly indicate thallium poisoning, and haemodialysis may be beneficial even in the third week after poisoning.
56 citations
,
January 2008 in “Dermatology” This article discusses the controversy over serum ferritin levels in diagnosing iron deficiency in women with hair loss but reports no new findings, emphasizing the need for consistent reference ranges.
55 citations
,
July 1983 in “Journal of the American Academy of Dermatology” This case study of three siblings highlights the importance of recognizing dermatologic signs—alopecia and periorificial dermatitis—for early diagnosis and treatment of biotin-responsive multiple carboxylase deficiency.
50 citations
,
May 2018 in “International journal of cardiology” This study found associations between genetic predictors of increased testosterone and cardiovascular risk factors, but the implications for testosterone supplementation are unclear due to uncertainties in genetic variant functions.
48 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the genetic and protein interactions involved in hair growth, highlighting regulatory sequences, expression patterns, and potential genetic modifications, but presents no new experimental findings.
47 citations
,
November 2010 in “Vox Sanguinis” This study found that a targeted iron supplementation program prevented anemia and improved blood return rates among premenopausal female blood donors with iron deficiency.
46 citations
,
May 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses the state-of-the-art knowledge on pseudoxanthoma elasticum, summarizing recent advancements in genetics, pathomechanisms, and potential treatments but reports no new clinical findings.
45 citations
,
June 1984 in “Journal of the American Veterinary Medical Association” In this study, zinc supplementation rapidly improved conditions such as anorexia, depression, and foot soreness in sheep and goats diagnosed with zinc deficiency, along with healing skin lesions and resumption of hair and wool growth.
43 citations
,
April 2005 in “The Journal of Dermatology” This case report describes a 5-month-old Japanese infant with biotin deficiency, where daily oral biotin supplementation led to significant improvements in skin conditions and hair growth.
41 citations
,
June 2022 in “Biomedicines” This study proposes reclassifying PCOS into two distinct phenotypes based on androgen levels and suggests androgen supplementation may overcome IVF resistance in one group with advancing age.
40 citations
,
January 2013 in “Journal of Korean Medical Science” This study found that serum ferritin levels were lower in premenopausal women with female pattern hair loss compared to healthy controls, suggesting a potential role for iron in hair loss.
39 citations
,
July 2007 in “SKINmed Dermatology for the Clinician” In this case study, a 4-year-old girl's hair loss stopped after six months of zinc supplementation and dietary changes, suggesting a possible link to low zinc levels.
35 citations
,
August 2010 in “The American journal of pathology” This study reports that hypomorphic alleles of the Ass1 gene in mice resemble human CTLN1, providing a potential model for preclinical studies and indicating that standard treatments for CTLN1 can rescue phenotypes.
30 citations
,
July 2019 in “Endocrinology” This review discusses how the HSD3B1(1245C) genotype may impact androgen physiology and the progression of castration-resistant prostate cancer, and does not report new experimental results.
30 citations
,
October 2009 in “Journal of Veterinary Internal Medicine” This report describes a unique case of hereditary vitamin D-resistant rickets (HVDRR) in a dog, caused by a VDR gene mutation resulting in severe hypocalcemia and bone issues, which presented with symptoms similar to those observed in humans.
29 citations
,
July 1996 in “Acta Paediatrica” This study found that an 11-month-old Japanese infant developed biotin deficiency while on a Japanese amino acid formula without biotin, which was resolved with biotin supplementation.
29 citations
,
February 1987 in “General and comparative endocrinology” This study found that in male badgers, seasonal molting and hair growth are influenced by cycles of plasma testosterone and thyroxine, with hormones affecting the timing and progression of these processes.
26 citations
,
March 2001 in “PubMed” This article reviews the effect of aging on male hormone levels and fertility, highlighting the need for more research on the benefits and risks of androgen supplementation in older men.
24 citations
,
December 2016 in “Psychiatric Clinics of North America” This review discusses hormonal and surgical gender-affirming interventions for transfeminine individuals, noting improvements in quality of life and mental health with minimal adverse effects, but reports no new research findings.