April 2016 in “Journal of The American Academy of Dermatology” People with hair loss have low zinc levels; zinc supplements and laser therapy may help.
207 citations
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April 2006 in “Journal of The American Academy of Dermatology” This review discusses the complexities of diagnosing and treating iron deficiency related to nutritional anemia and hair loss, concluding that routine screening and supplementation for hair loss are not yet supported by sufficient evidence.
73 citations
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May 1976 in “JAMA” This case report associates severe zinc deficiency with long-term total parenteral nutrition, suggesting the need for trace element supplementation in such nutritional management.
37 citations
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June 2018 in “Clinical and Experimental Medicine” This study found that patients with alopecia areata had significant systemic inflammation and vitamin D deficiency, with both conditions more pronounced as disease severity increased.
36 citations
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January 2017 in “Journal of Obstetrics and Gynaecology Research” This review discusses the association between vitamin D receptor polymorphisms and polycystic ovary syndrome, noting the need for further research on their impact on the disorder's manifestations.
34 citations
,
August 2005 in “Veterinary Dermatology” This descriptive study reports that zinc deficiency in two dairy goats likely resulted from hereditary malabsorption, requiring life-long zinc supplementation to prevent skin lesions.
32 citations
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December 2017 in “International Journal of Molecular Sciences” This review suggests that decreased serum 25-hydroxyvitamin D levels may play a role in different types of non-scarring alopecia, but further studies are needed to explore vitamin D supplementation as a therapeutic option.
28 citations
,
April 2017 in “Journal of cosmetic dermatology” This study found that while vitamin D deficiency is not the sole cause of alopecia areata, it may worsen the disease, suggesting supplementation could help in pediatric cases.
21 citations
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June 2011 in “Journal of child neurology” This study found that while serum zinc levels were lower in children treated with valproic acid or carbamazepine than in healthy controls, zinc, biotin, and biotinidase enzyme activity remained within normal ranges and unaffected by these treatments.
20 citations
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January 2019 in “International journal of trichology” This study found that patients with alopecia areata had significantly lower Vitamin D levels compared to controls, with a negative correlation between Vitamin D levels and disease severity.
19 citations
,
September 2010 in “The American journal of pathology” This study demonstrated that elevated glucocorticoid levels in transgenic mice led to pancreatic exocrine cells transforming into hepatocyte-like cells, resulting in pancreatic dysfunction.
16 citations
,
November 2021 in “Antioxidants” This review examines the role of oxidative stress in male hypogonadism associated with noncommunicable chronic diseases and discusses various management strategies, but it presents no new clinical findings.
15 citations
,
January 2016 in “International journal of trichology” This study found that female students experiencing diffuse hair fall had significantly lower Vitamin D3 levels compared to healthy controls.
13 citations
,
April 2019 in “Actas Dermo-Sifiliográficas” This review discusses the relationship between vitamin D and various skin diseases, highlighting recent findings on its role and the importance of assessing and correcting vitamin D levels, but reports no new clinical results.
11 citations
,
January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses current and emerging therapies for alopecia areata, highlights the challenges in managing this chronic disease, and emphasizes the importance of addressing its psychosocial impacts; it reports no new clinical results.
11 citations
,
May 2021 in “Journal of Medical Virology” This review discusses sex differences in immune response to respiratory viral infections, including SARS-CoV-2, and highlights that hormones like estrogen may provide females with better protection, but it reports no new results.
11 citations
,
January 2014 in “Egyptian Journal of Dermatology and Venereology” This study found that women with female-pattern hair loss had significantly lower serum levels of 25-hydroxyvitamin D compared to healthy controls, but it does not establish causation.
9 citations
,
December 2021 in “Androgens” This review explores how androgen administration might help alleviate inflammation and mitochondrial impairment in traumatic brain injury but reports no new experimental findings, calling attention to the need for further investigation.
8 citations
,
June 2020 in “International Journal of Dermatology” This study found a significant correlation between vitamin D deficiency and the severity of androgenetic alopecia in males, suggesting that vitamin D may influence the condition's premature onset.
7 citations
,
May 2012 in “Journal of veterinary diagnostic investigation” This study reports that vitamin A deficiency can cause dermatologic issues like alopecia and orthokeratosis in Angus calves, and affected calves improved with vitamin A supplementation.
6 citations
,
August 2023 in “Journal of Investigative Dermatology” This study investigated how keratinocytes in the skin respond to different iron levels and found they play a significant role in regulating iron homeostasis by storing iron, affecting epidermal differentiation, and influencing inflammation-related gene expression in mice.
6 citations
,
August 2020 in “Dermatology and Therapy” This study found that patients with alopecia areata had significantly lower serum vitamin D levels and higher odds of vitamin D deficiency, but no significant difference in serum calcium levels, compared to controls.
5 citations
,
February 2025 in “Cell Reports” In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.
5 citations
,
January 2012 in “Indian Journal of Dermatology Venereology and Leprology” Werner's syndrome causes early aging and increases cancer risk, requiring early diagnosis and symptom management.
4 citations
,
May 2017 in “Pediatric Dermatology” This case report details a 3-year-old girl with short anagen syndrome, characterized by short, sparse hair, where X-ray microanalysis showed her hair's main bioelements were normal.
4 citations
,
October 1998 in “In Practice” This article outlines a practical method for diagnosing and managing feline symmetrical alopecia but presents no new empirical findings.
3 citations
,
November 2021 in “Applied Microscopy” This article presents a comprehensive overview of hair microscopy techniques and their diagnostic potential for systemic and cutaneous disorders, emphasizing its usefulness in resource-limited settings and highlighting the underutilization of this non-invasive method due to lack of awareness.
2 citations
,
May 2011 in “British Journal of Dermatology” This review discusses the diagnosis and treatment of pellagra, emphasizing the importance of evaluating serum niacin levels in photosensitive patients with certain risk factors, and reports no new clinical results.
1 citations
,
October 2025 in “Journal of Personalized Medicine” This review discusses various weight loss treatment options for managing PCOS in women, including lifestyle changes, diet, medications, and surgery, but reports no new clinical results.
1 citations
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June 2019 in “Current developments in nutrition” This case study reports that pancreatic enzyme replacement and fatty acid supplementation improved symptoms of fat malabsorption and essential fatty acid deficiency in a patient with EDS-4.