January 1990 in “Advances in forensic haemogenetics” This study used one-dimensional SDS electrophoresis to examine low sulfur proteins in hair samples from multiple generations within five families, but does not report new results.
67 citations
,
December 1990 in “The journal of cell biology/The Journal of cell biology” This study identified two evolutionarily conserved ultra-high-sulfur keratin proteins in human and sheep hair follicles, which are specifically expressed in the hair cuticle during the late stages of fiber development.
34 citations
,
September 2007 in “Experimental Dermatology” This study found that the outer protein layer of Merino wool is rich in sulfur-containing proteins similar to those found in both sheep wool and human hair.
4 citations
,
January 2015 in “Journal of microbial & biochemical technology” In this study, the researchers observed that biotin administration in biotin-deficient children with alopecia eliminated certain membrane proteins from their blood, suggesting that biotin might regulate these proteins' expression.
This study found that culturing hair follicles at the air-liquid interface enhanced hair growth and maintained an anagen-like morphology better than submerged cultures.
26 citations
,
September 1990 in “Ophthalmology” This case study found that a 7-year-old girl's crystalline cataract had sulfur-containing amino acids likely cystine, and was associated with abnormal hair conditions.
16 citations
,
March 2015 in “Dermatologic therapy” This study reported two cases of alopecia areata where hair regrowth was achieved with zinc gluconate and sulfur amino acids after relapse post-PUVA cessation, suggesting potential zinc responsiveness in some patients.
11 citations
,
March 2023 in “Frontiers in Nutrition” This study found that a modest increase in dietary zinc over six months resulted in a detectable increase in sulfur and zinc counts in individual hairs, suggesting a non-invasive method to monitor zinc intake effects.
1 citations
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December 2005 in “Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale” This study used Scanning Electron Microscopy to analyze South American mummy hair, revealing high levels of sulfur, calcium, and potassium, highlighting SEM's utility in anthropological investigations.
January 1991 in “Acta Dermato Venereologica” This article describes a new method for staining hair fibers that visualizes keratin filaments without the need for OsO4 fixation or sulfur bond breakage, but it provides no new experimental results beyond the method itself.
5 citations
,
January 2024 in “Crystals” This study characterized the crystal structures and supramolecular architectures of new salts made from 2,4-diaminopyrimidine and different dicarboxylic acids, revealing subtle differences in crystal packing and hydrogen-bonding patterns, particularly influenced by sulfur atom interactions, through Hirshfeld analysis and enrichment ratios.
3 citations
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September 2021 in “Data in brief” This study observed that bleaching brown human hair with persulfate salts and hydrogen peroxide induced significant conformational changes in keratin, particularly affecting disulfide bridges and oxidized sulfur species, which may inform the development of hair restorative treatments.
July 2018 in “International journal of clinical & experimental dermatology” This narrative review describes the components of human hair and their nutritional importance but reports no clinical results; the authors suggest dietary sulfur amino acids are essential for hair health.
38 citations
,
May 2000 in “Livestock production science” This study found that good quality protein supplements or rumen-protected methionine increased fiber yield in Angora goats and, to a lesser extent, in Cashmere goats.
16 citations
,
January 2010 in “American Journal of Neuroradiology” This case report describes a 3-year-old boy with trichothiodystrophy, highlighting specific MRI findings of diffuse dysmyelination and osteosclerosis that may be unique to the disorder.
May 2024 in “Biochemical pharmacology” This study found that targeting CISD1 with the compound NL-1 reduced mitochondrial dysfunction and reactive oxygen species accumulation, protecting against cisplatin-induced hearing loss in cell models and mice, without affecting cisplatin's cancer-fighting effectiveness.
5 citations
,
February 1998 in “Polymer” Human hair keratin has a 40% α-helix structure that changes to a random coil in 8 M urea.
2 citations
,
January 2018 in “International Journal of Trichology” This case report describes trichothiodystrophy in two sisters with only hair fragility, illustrating the condition's variable presentation and the importance of regular monitoring for potential associated impairments.
20 citations
,
June 2022 in “Molecules” This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.
58 citations
,
November 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mutations in the Foxn1 gene in nude mice affect not only hair but also nail structure and differentiation, offering insights into nail hypergranulosis pathogenesis relevant to human nail diseases.
29 citations
,
December 2017 in “Molecular therapy” This study found that enzyme replacement therapy in mice with a severe form of classical homocystinuria improved metabolic patterns and alleviated many clinical symptoms.
15 citations
,
January 1981 in “Neonatology” This study observed that changes in amino acid levels in milk correlate with developmental events in pouch young marsupials, notably around hair follicle development and homeothermy onset.
6 citations
,
January 2006 in “Journal of dermatological science” Runx1 helps control the KAP5 gene in human hair follicles.
4 citations
,
January 1981 in “PubMed” This study found that medullary cell content in mammal hair evolves from an amorphous form to a biphasic phase, with human and anthropoid hair containing both macrofibrils and microfibrils.
This research observed that hairless guinea pig dermal fibroblasts were more sensitive to a toxic exposure than human dermal fibroblasts, suggesting that guinea pigs might serve as an intermediate model for translating in vitro findings to whole organisms.
October 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review reports that onion-derived products, like juice and oil, show potential benefits for hair regrowth in alopecia areata and scalp health due to their rich phytochemical content, but notes that further standardized formulations and rigorous clinical trials are needed to substantiate these effects.
October 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This review synthesizes current research on onion-derived preparations for scalp and hair health, highlighting their potential benefits in hair regrowth, microbial reduction, and follicular support, while noting gaps in standardized formulations and controlled clinical trials.
This study found that four synthesized thiazolidinone derivatives showed potential anticancer activity against MCF7 and HeLa cell lines, suggesting their further investigation for anticancer drug development.
April 2012 in “Neuropediatrics” This article reviews the genetic and phenotypic characteristics of Trichothiodystrophy and discusses the associated DNA repair defects, but does not report new clinical findings.
January 1980 in “AFA Watchbird” This report suggests that spectral-analysis of feathers may identify toxic mineral exposure in birds, as illustrated by a cockatoo with feather loss showing high levels of aluminum and cadmium.