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January 2016 in “Journal of Microbial & Biochemical Technology” This study found that the free androgen index (FAI) is a superior marker of hyperandrogenism in men with premature androgenetic alopecia compared to DHEAS and testosterone levels.
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November 2008 in “Acta crystallographica” This study reports the crystallization of the human androgen receptor's ligand-binding domain with nonsteroidal ligands, which may aid in understanding the differences in binding compared to steroidal ligands.
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January 1992 in “Juntendō Igaku/Juntendo igaku” This review discusses the hair growth mechanisms of minoxidil, suggesting both increased blood flow and a direct effect on hair follicles, but reports no new clinical results.
July 2026 in “Journal of the American Academy of Dermatology” CRT is more effective than oral minoxidil alone for treating hair loss.
June 2026 in “Journal of Biomedical Materials Research Part B Applied Biomaterials” This study found that a hydrogel made from human placenta-derived ECM, copper, and endothelial progenitor cells significantly enhanced pressure ulcer healing in a mouse model by improving wound closure and tissue regeneration.
May 2026 in “Revista Ensaios Pioneiros” This study developed and evaluated topical formulations containing 5% minoxidil and 1% rosemary essential oil for androgenetic alopecia treatment, finding them physically and chemically suitable, but noted that further stability tests and clinical trials are needed to confirm therapeutic efficacy and safety.
May 2026 in “Research Square” In this study of women aged 18-45 from an endocrine referral group, researchers found that while clinical hirsutism severity is independently associated with biochemical hyperandrogenism, the relationship is modest and suggests different biological aspects are at play.
This study found that finite element analysis-guided design improved bubble microneedles' controlled tip separation and insertion strength, supporting effective transdermal and sublingual drug delivery.
This study developed a co-design framework using finite element analysis to optimize bubble microneedles, achieving controlled tip separation and effective drug delivery through the skin and mucosa while maintaining insertion strength.
May 2026 in “Drug Delivery” This study introduces a co-design framework using finite element analysis to optimize separable bubble microneedles, demonstrating enhanced transdermal and sublingual drug delivery in preclinical models. In vivo results showed faster hair regrowth and glucose lowering in animals, indicating potential improvements over traditional methods.
March 2026 in “Journal of the American Academy of Dermatology” Lower doses of oral minoxidil can promote hair growth without major heart risks.
March 2026 in “Endocrine Metabolic & Immune Disorders - Drug Targets” This study found that in women with PCOS, a combination of finasteride and spironolactone significantly improved all health-related quality of life scales and reduced hyperandrogenism within four months, supporting its role alongside lifestyle measures.
March 2026 in “Journal of Biomedical Materials Research Part B Applied Biomaterials” This study found that a chitosan, chondroitin sulfate, and hyaluronic acid scaffold improved wound healing in rats by promoting immune-stromal interactions, reducing inflammation, and supporting tissue regeneration with ~91% wound closure by day 17 compared to ~63% in controls.
February 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study found that hirsutism and acne are strong predictors of biochemical hyperandrogenism in women with polycystic ovary syndrome.
January 2026 in “International Society of Hair Restoration Surgery” This study reports that a novel multimodal approach, combining tattoo machine–assisted drug delivery of hair loss treatments with oral and topical medications, may enhance hair density and thickness in androgenetic alopecia patients, though larger controlled studies are needed to confirm these early findings.
January 2026 in “Dermatologic Therapy” This review found that circulating dihydrotestosterone (DHT) consistently distinguishes men with androgenetic alopecia from controls, suggesting a key role in the condition's biology and potential therapeutic targeting.
December 2025 in “Sustainable Chemistry One World” In this study, researchers found that mangosteen pericarp extract, combined with FeSO₄ as a mordant, effectively produced a stable reddish hair dye on bleached hair, with good color persistence and enhanced tensile strength, indicating its potential as an eco-friendly and safer alternative to synthetic dyes.
November 2025 in “Basic and Clinical Andrology” This systematic review and meta-analysis found that male first-degree relatives of women with PCOS have increased rates of metabolic issues, hormonal imbalances, and androgenic features compared to controls, suggesting a male equivalent of PCOS.
October 2025 in “Journal of the Endocrine Society” This case study reported a unique instance of a benign adrenal adenoma co-secreting cortisol and DHEA-S, which initially mimicked PCOS symptoms. Surgical removal resulted in significant clinical improvement, confirming the diagnosis of cyclic adrenal Cushing's syndrome.
October 2025 in “Indian Journal of Paediatric Dermatology” This case study documents a boy with zinc-responsive acral hyperkeratosis improving significantly after zinc supplementation, suggesting it could result from inadequately treated acrodermatitis enteropathica.
October 2025 in “Journal of Bahria University Medical and Dental College” In this study, among women with polycystic ovary syndrome, free testosterone was most frequently elevated, highlighting its importance in biochemical assessment and suggesting the need for age-related interpretation of DHEAS levels.
September 2025 in “International Journal of Zoology and Applied Biosciences” This study found that women aged 21-26 with PCOS showed significant differences in biochemical and hormonal profiles, such as blood sugar and hormone levels, compared to healthy individuals, suggesting an increased incidence of PCOS in this age group.
September 2025 in “British Journal of Hospital Medicine” This study found that certain plasma protein ratios, specifically AGRN/HSPG2 and DECR1/FKBP1B, were significantly associated with an increased risk of alopecia areata, indicating potential causal relationships but reverse causality was not supported.
June 2025 in “V F Snegirev Archives of Obstetrics and Gynecology” In this case study, a six-year-old girl was diagnosed with isolated adrenarche, linked to premature adrenal maturation, with increased dehydroepiandrosterone sulfate and axillary and pubic hair growth, and will require long-term monitoring due to increased risks of conditions like polycystic ovary syndrome and cardiovascular diseases.
May 2025 in “International Ayurvedic Medical Journal” In this case study, a 38-year-old woman with alopecia areata experienced significant improvement in hair regrowth after treatment with rakthamokshana and a herbal lepa containing Shodita Kasisa and Triphala masi mixed with nilibringaraj taila.
In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.
April 2025 in “Middle East Fertility Society Journal” This study established reference values for nine fertility hormones important in diagnosing and monitoring PCOS in Pakistani and other subcontinent populations.
March 2025 in “Archives of Dermatological Research” Early-onset hair loss in Egyptian males is linked to genetics, hormones, and lifestyle factors like smoking and diet.
February 2025 in “Pharmaceuticals” This study found that supplementing myo-inositol with microlipodispersed magnesium significantly improved acne and hirsutism in women with PCOS by reducing BMI, testosterone, and DHEAS levels, also enhancing quality of life without side effects, over 6 months.
February 2025 in “Journal of Cosmetic Dermatology” This study examined the sensitization potential of common hair care products and found that certain ingredients, like cobalt chloride and nickel sulfate, frequently cause allergic reactions in individuals with hair diseases, providing essential insights for personalized treatment strategies.