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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Early diagnosis and treatment, using finasteride, minoxidil, or hair transplantation, improves hair loss outcomes.

Sebocytes play a key role in controlling androgen levels in human skin.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Some medicinal plants can help heal wounds and may lead to new treatments.

Latanoprost can make eyelashes longer, thicker, and darker.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

The document concludes that accurate diagnosis of ichthyosis is crucial for treatment and genetic advice, and ongoing research is needed for better therapies.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.