25 citations
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September 2024 in “Cardiovascular Drugs and Therapy” This study found that while glucagon-like peptide 1 receptor agonists report more incidents of suicide, hair loss, and aspiration compared to some other antidiabetic drugs, they did not meet the threshold for positive safety signals.
November 2024 in “Circulation” This study found that GLP1-RAs, while not triggering significant safety signals, were reported more often for suicide, hair loss, and aspiration events compared to some other diabetes medications.
September 2025 in “Turkish Journal of Dermatology” This study found that children with alopecia areata had higher levels of oxidative stress markers but showed no significant differences in depression and suicide tendencies compared to healthy peers.
March 2025 in “Journal of Cosmetic Dermatology” This study found that reports of suicidal ideations linked to oral finasteride were significantly higher in 2013–2018 and 2019–2023 compared to 2006–2011, potentially due to increased awareness of post-finasteride syndrome from 2012 onward. No such signals were seen with oral dutasteride.
May 2026 in “Reactions Weekly” Finasteride and dutasteride may increase the risk of suicide and sexual dysfunction.
June 2026 in “The Pharmacogenomics Journal”
Dr. Mayer Brezis argues that a study by Wang et al. incorrectly concluded that finasteride does not cause depression or suicide, due to methodological flaws, and suggests halting its marketing under the precautionary principle.
In this letter, Dr. Mayer Brezis critiques a study on finasteride's mental health impact, arguing that its dismissal of links between the drug and depression or suicide is flawed; he suggests market withdrawal due to established neuropsychiatric risks.
September 2025 in “Therapies” This study found that finasteride is associated with significant depressive effects, including an increased risk of suicidality, which can persist beyond 20 months after stopping the medication, even without prior sexual dysfunction or psychiatric history.
December 2022 in “JAMA network open” This study found that men using 5-alpha-reductase inhibitors showed an increased risk for dementia shortly after starting treatment, which diminished over time, and a consistent association with depression, but no link to suicide.
2 citations
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July 2019 in “Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg)” This article reviews the use of isotretinoin for acne treatment and its controversial association with depression and suicide, noting limited evidence for a direct link.
June 2025 in “Clinical and Experimental Dermatology” In this study, the researchers found no link between finasteride use and increased suicide attempt risk among Danish males, noting unadjusted and adjusted odds ratios close to one.
December 2025 in “Journal of Cosmetic Dermatology” This study found that finasteride use is not significantly associated with an increased risk of depression or suicide, based on Mendelian randomization analysis and COX regression analysis in a large UK Biobank cohort.
6 citations
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January 2020 in “Dermatology” This study suggests that men under 40 who develop persistent sexual side effects and insomnia after using finasteride for alopecia may be at increased risk of suicide.
January 2020 in “Figshare” In this study, men under 40 using finasteride for alopecia who experienced persistent sexual side effects and insomnia were reportedly at risk for suicide.
May 2024 in “European urology focus” In this systematic review and meta-analysis, the authors found no statistically significant association between the use of 5α-reductase inhibitors and the risk of depression or suicide among over two million studied patients.
July 2026 in “Journal of the American Academy of Dermatology” Finasteride may lower depression risk in younger men with hair loss but increase it in older men with prostate issues.
August 2018 in “Journal of The American Academy of Dermatology” Finasteride use for hair loss is linked to an increased risk of suicidal thoughts and a higher risk of suicide.
August 2018 in “Journal of The American Academy of Dermatology” The conclusion is that finasteride is linked to an increased risk of suicidal thoughts and a higher risk of completed suicide when used for hair loss.
November 2021 in “Evidencia” In this study, the use of finasteride in young patients may be linked to a higher risk of anxiety, depression, and suicide-related adverse events.
1 citations
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March 2023 in “Scientific Reports” This cohort study found no overall increased risk of suicidal behaviors with finasteride versus dutasteride in men aged 50 and older, but suggested potential risk for those with a history of mood disorders.
This nested case-control study observed that patients with benign prostatic hyperplasia or androgenic alopecia who had a cumulative 5-ARI dose exceeding 5840 defined daily doses had a significantly reduced mortality risk, while lower doses were linked to higher mortality and suicide rates.
May 2017 in “Psychiatric news” This study found that seniors using finasteride or dutasteride for benign prostatic hyperplasia may have an increased risk of depression and self-harm, especially during the first 18 months of treatment.
April 2022 in “The Journal of Sexual Medicine” This study suggests that using finasteride for alopecia or BPH may be less associated with suicidality and psychological adverse events when combined with PDE5 inhibitors or testosterone, possibly offering protective benefits.
July 2026 in “Postgraduate Medicine” Results are not reported in this commentary, but it discusses the influence of different control group choices—an active-comparator versus non-drug users—on measuring depression risk in studies of 5-alpha reductase inhibitors.
2 citations
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November 2021 in “Journal of Clinical Psychopharmacology” This article provides no new research results, focusing instead on International Consortium for Mood and Psychotic Disorder Research's topics and types of collaborations.
30 citations
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April 2007 in “Dermatologic Clinics” This review discusses the mechanisms by which isotretinoin and hormonal therapy treat acne through their effects on sebaceous glands, reporting no new clinical results.
August 2018 in “Journal of The American Academy of Dermatology” Finasteride, a hair loss drug, is linked to increased suicidal thoughts, particularly when used for hair loss.
April 2026 in “Brain Sciences” This pharmacovigilance study analyzed FAERS data and found that finasteride is more frequently associated with neuropsychiatric reactions like depression and suicide risk, especially in younger men using it for alopecia, compared to dutasteride.
This article compiles various topics in psychodermatology, such as suicide risk, treatment options, and the psychological impact of conditions like alopecia, but reports no new clinical findings.