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The lowest effective dose of Botox for detrusor sphincter dyssynergia is between 75-100 units.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.

Cannabinoids may help treat chronic and chemotherapy-induced neuropathic pain, but more research is needed to confirm their effectiveness and safety.

Testosterone therapy can help improve sexual desire and function in postmenopausal women but may cause side effects and is not FDA-approved for this use.

Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.

Bariatric surgery may help severely obese teenagers but has risks and requires careful patient selection and long-term care.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Scientists have made progress in creating replacement teeth, hair, and glands that work, which could lead to new treatments for missing teeth, baldness, and dryness conditions.

New drugs and combination therapies are improving treatment for lower urinary tract symptoms.

The document concludes that there are still unknowns about the effectiveness, risks, and detection of performance-enhancing drugs, and doping remains a challenge.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

Primary care doctors should address female sexual dysfunctions to improve women's sexual health and life quality.

The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.

PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.

Testosterone is crucial for development, growth, and various body functions in mammals.

The document concludes that gender-affirming treatments are essential for transgender individuals and outlines safe hormone therapy practices.

A 23-year-old woman with Hashimoto’s thyroiditis improved significantly after a 15-month integrative treatment plan.

JAK inhibitors for alopecia areata are linked to minor side effects like headache and acne, but not to an increased risk of serious adverse events.

The healthcare for transgender veterans could be better with a more unified team approach.

SCDSFs from zebrafish embryos are beneficial for treating cancer, regenerating tissues, and improving conditions like psoriasis and alopecia.

Adult earlobe can have a benign cyst that is usually removed by surgery.