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Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.

This study examined 4-azasteroids using 13C-NMR spectroscopy, detailing the NMR spectrum assignments and reporting a new molecular complex of finasteride with dioxane.

Caloric restriction improves skin and fur structure but can cause muscle loss and movement issues.

This study described the structure of the hair brush on male Endoclita vietnamensis moths' legs, identifying characteristics such as specialized scales and a pheromone gland, which could facilitate the future development of pheromone-based pest control methods for eucalyptus pests in China.

In this study, structural and functional brain abnormalities specific to visuospatial and somatosensory processing networks were observed in patients with anorexia nervosa, highlighting a critical role for the precuneus.

This study found significant species differences in the enzyme activity and inhibitor affinities of prostatic 5α-reductases from rats, dogs, and humans, with variable potencies for different 3-oxo-4-azasteroid inhibitors across species.

This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.

This study reports that human epidermal transglutaminase activity increases with treatment using organic solvents and chemicals without significant molecular weight changes, which may allow modulation of the enzyme in skin diseases.

This study found that PT-LCG extends hair follicle activity and promotes continuous cashmere growth by enhancing lipid synthesis, remodeling the extracellular matrix, and modulating inflammatory signaling, offering insights into improving cashmere yield and quality through molecular breeding.

This study constructed a model to predict finasteride's inhibitory activity on 5α-reductase type 2 and calculated that a 1 μM plasma concentration, after 50 mg administration, matches prostate inhibition levels.

This study found that the yeast androgen screen (YAS) could detect the activity of methyltestosterone in urine for a longer period than classical GC/MS, potentially identifying long-lasting metabolites.

In this study, a novel silver nanowires/collagen I/bacterial cellulose dressing demonstrated strong antibacterial activity and enhanced wound healing capabilities, while showing improved cytocompatibility and mechanical properties compared to traditional silver nanowire-based dressings.

In this study, silver nanoparticles synthesized using Pogostemon benghalensis extract demonstrated significant antibacterial activity, antioxidant properties, and potential anticancer effects, particularly showing effectiveness against V. cholerae and A549 lung cancer cells through apoptosis.

This study found that four synthesized thiazolidinone derivatives showed potential anticancer activity against MCF7 and HeLa cell lines, suggesting their further investigation for anticancer drug development.

This study suggests that two approved drugs may inhibit the SARS-CoV-2 helicase based on significant activity in laboratory models, offering hope for potential COVID-19 treatments.

This study found that newly synthesized steroidal trienones demonstrated stronger 5α-reductase inhibitory activity compared to dienones in various biological models, suggesting potential for developing enhanced antiandrogenic drugs.

This study demonstrates that the amino-terminally shortened KGF-1 variant with 135 residues maintains biological activity, suggesting it may serve as an alternative to the original KGF-1 for certain therapeutic applications.

This study found that encapsulating dermal papilla spheroids in alginate hydrogel with extracellular matrix proteins increased alkaline phosphatase activity, suggesting an enhanced manipulation of dermal papilla activity.

This study observed that new trienone compounds consistently showed higher 5alpha-reductase inhibitory activity compared to corresponding dienones across various biological models.

In this study, researchers found that specific enzyme activities in young females' hair follicles were correlated with changes in hair shaft structure and properties, and permanent waving was associated with chemical changes that suggest hair damage.

This study observed that long-term laser hair removal in women may alter hair follicle structures and stem cell interactions, with dermal fibrosis potentially influencing hair regrowth prevention.

This study found that the optimized AR antagonist compound 39 showed potent hair growth activity with improved safety in mice, suggesting potential for better topical treatments for androgenetic alopecia.

This study found that sympathetic nerves and arrector pili muscles form a niche that modulates hair follicle stem cell activity, revealing their role in hair follicle regeneration.

This study developed a nanofiber wound dressing combining ciprofloxacin and tetracycline hydrochloride, which demonstrated strong antibacterial activity against E. coli and S. aureus and showed good biocompatibility with human skin fibroblast cells, indicating significant potential for wound healing applications.

This study found that among the two highly homologous K16 genes on chromosome 17, only one produced a functional protein due to stronger promoter activity.

This study found that transplanted microencapsulated dermal papilla cells in rat footpads can regenerate hair follicles and sebaceous gland structures, suggesting a potential substitute for fresh dermal papillae cells.

This study found that colchicine treatment significantly reduced hair fiber elongation in cultured hair follicles and altered protein expression and activity in dermal papilla cells, suggesting a role for the ubiquitin-proteasome system in its effects.

In this study, targeted overexpression of the BMP receptor ALK2 in mouse hair follicle stem cells altered follicle structure and impaired cutaneous wound healing.

In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.