March 2015 in “Plastic and reconstructive surgery” This chapter reviews the skin's structure and its clinical relevance, highlighting connective tissue diseases and the potential for novel treatments like protein, cell, or stem cell transfer, but reports no new findings.
December 1991 in “Annals of the New York Academy of Sciences” This article discusses themes in the molecular structure of hair and reports no new research findings.
86 citations
,
December 2001 in “Experimental dermatology” This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.
25 citations
,
May 2019 in “Heliyon” This study found that excessive heat caused the most significant structural changes in hair from Caucasian and Afro samples, especially when combined with other treatments like bleaching and straightening.
15 citations
,
July 2004 in “Journal of morphology” This study analyzes the fine structure and protein distribution in monotreme hairs, finding similarities with other mammals and detailing unique immunocytochemical features in their inner root sheaths.
6 citations
,
April 2022 in “Frontiers in cell and developmental biology” This study identified differentially expressed proteins and pathways potentially involved in wool bending in Zhongwei goats, with specific genes like COL6A1 and CRNN emerging as important candidates in this process.
4 citations
,
February 2022 in “Frontiers in molecular biosciences” This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
38 citations
,
July 2021 in “ACS Nano” This study found that a ceria nanozyme-integrated microneedles patch accelerated hair regeneration in an androgenetic alopecia mouse model more effectively than minoxidil, with reduced application frequency and minimal skin damage.
30 citations
,
April 2017 in “Journal of structural biology” This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.
24 citations
,
November 2015 in “Scientific reports” This study discovered a new region in the hair cortex where intermediate filaments are both aligned with the hair's axis and orientationally ordered, influenced by the cuticle boundary.
16 citations
,
January 2017 in “Physical chemistry chemical physics/PCCP. Physical chemistry chemical physics” This study presents computational modeling and experimental analysis of the HGT protein KAP8.1, identifying key structural features that may influence hair's response to environmental conditions.
12 citations
,
April 2016 in “Chinese Medicine” The research identified 12 antioxidant compounds in Polygonum multiflorum roots, suggesting these as quality markers for the plant's processed roots.
4 citations
,
October 2014 in “Springer eBooks” This chapter reviews the roles of ethylene and auxin in seedling growth and development and reports no new experimental results; it highlights recent studies on their mechanistic crosstalk.
This study found that inhibiting the Mitochondrial Pyruvate Carrier in human scalp hair follicles caused metabolic stress that halted cell proliferation and disrupted key signaling pathways, with these effects partially reversed by an integrated stress response inhibitor.
July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that extracellular matrix scaffold membranes performed less effectively in wound healing for aged mice compared to younger ones, with senescent SPP1+ macrophages potentially hindering epidermal and fibroblast repair abilities.
4 citations
,
July 2025 in “Frontiers in Immunology” This study explored peripheral blood immune dysregulation in alopecia areata through single-cell analyses, identifying systemic changes linked to disease severity and key signaling roles for monocytes, NK cells, and memory T cells, suggesting potential therapeutic targets.
2 citations
,
October 2004 in “Drug Information Journal” The conclusion is that combining social and cultural factors with pharmaceutical research could improve our understanding of how drugs work.
1 citations
,
July 2017 in “Microbial Cell Factories” This study found that supplementing soybean oil significantly increased the production of the cyclosporine A derivative [(4'-OH)MeLeu]4-CsA by 55.6%, offering potential enhancements for its clinical application.
This review explores psychodermatology and platelet-rich plasma as complementary approaches for enhancing patient-centered care in dermatology, reporting no new results but highlighting their potential to improve outcomes and quality of life.
July 2024 in “Annals of Phytomedicine An International Journal” In this study, the authors reviewed various herbal ingredients used in hair care products and found that components like aloe vera, hibiscus, amla, and fenugreek have traditional and scientifically validated benefits for addressing hair issues such as hair loss, dandruff, and damage.
36 citations
,
January 2014 in “Elsevier eBooks” This narrative review discusses the structure and functions of the skin, focusing on its barrier role, self-repair, thermoregulation, and immune functions, and reports no new experimental results.
This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.
December 2025 in “Universal library of medical and health sciences.” This study analyzes contemporary theories and practices to understand key factors influencing the development of the examined phenomenon, proposing trends and practical applications for researchers and practitioners, while acknowledging study limitations and suggesting future research directions.
September 2025 in “Sahel Journal of Life Sciences FUDMA” This study reported that albino Wistar rats exposed to chemical hair straighteners showed significant hair fiber damage and scalp skin deterioration, which worsened with repeated and prolonged application, highlighting the cytotoxic potential of these products and potential systemic risks.
13 citations
,
April 2022 in “Frontiers in oncology” This review discusses the early phases of melanomagenesis and the factors influencing melanoma cell variability and reports no new clinical results.
12 citations
,
September 2021 in “The International Journal of Developmental Biology” This review updates on the development of liposomal carriers for delivering growth factors to improve tissue regeneration and highlights recent efforts to enhance their stability and retention in tissues.
4 citations
,
January 2015 in “Sen'i Gakkaishi” This study proposed a network model for the cross-linked structure of keratin-associated proteins in hair and wool fibers, suggesting notable differences between the two, potentially affecting hair fiber elasticity.
This chapter provides an overview of the complex chemical and physical structure of the hair surface, detailing how factors like ethnicity, environmental stress, and cosmetic treatments can alter its properties and influence the adhesion of hair care products.