50 citations,
May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.
47 citations,
March 2022 in “Frontiers in cellular and infection microbiology” Changes in skin microbes play a role in some skin diseases and could lead to new treatments.
9 citations,
April 2023 in “Frontiers in immunology” New technologies help us better understand how skin microbes affect skin diseases.
1 citations,
March 2024 in “Signal transduction and targeted therapy” NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
57 citations,
March 2018 in “International Journal of Molecular Sciences” The extracellular matrix is crucial for controlling skin stem cell behavior and health.
March 2024 in “Journal of functional foods” Collagen peptides from marine and bovine sources may help prevent hair loss by affecting hair follicle stem cells differently.
June 2024 in “Journal of Allergy and Clinical Immunology” TSLP affects atopic dermatitis by increasing sebum and reducing fat through IL-4/IL-13 signaling.
44 citations,
September 2014 in “Cell Death & Differentiation” Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.
1 citations,
October 2017 in “Elsevier eBooks” Antiandrogens can treat female hormonal conditions, but environmental ones may harm reproductive health.
26 citations,
May 2012 in “Cellular and Molecular Life Sciences” NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” A new staining method shows a special area in the hair's skin layer with lots of proteoglycans.
5 citations,
October 2014 in “Methods” The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.
451 citations,
March 2005 in “Endocrine Reviews” The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
108 citations,
February 2008 in “The Journal of urology/The journal of urology” Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.
98 citations,
December 2003 in “The FASEB Journal” Thymosin β4 promotes hair growth by activating stem cells in hair follicles.
71 citations,
February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
59 citations,
March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.
43 citations,
November 2013 in “Journal of Investigative Dermatology” Organotypic culture systems can grow skin tissues that mimic real skin functions and are useful for skin disease and hair growth research, but they don't fully replicate skin complexity.
31 citations,
January 2017 in “Advances in Experimental Medicine and Biology” Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.
20 citations,
March 2005 in “Current Medicinal Chemistry” New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
18 citations,
December 2018 in “Expert Opinion on Biological Therapy” Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.
16 citations,
January 2011 in “Archives of Dermatological Research” The study found that expanded skin regenerates similarly to normal skin, with 77 genes playing a role in the process.
14 citations,
April 2005 in “Experimental Dermatology” Stressed fibroblasts greatly increase melanin production in hair, skin, and eye cells, mainly due to a growth factor called bFGF.
6 citations,
March 2021 in “Journal of Cosmetic Dermatology” PRP injections promote hair growth and increase hair density in androgenic alopecia.
6 citations,
September 2012 in “Clinical Interventions in Aging” Honokiol might help reduce male skin aging by maintaining testosterone levels.
3 citations,
August 2021 in “Uro” Saw palmetto may improve urinary symptoms with fewer sexual side effects compared to some medications.
2 citations,
February 2017 in “International Journal of Molecular Sciences” Erdr1 could be a new marker for diagnosing hair loss.
June 2024 in “Georgetown medical review” Finasteride treats hair loss but may cause low libido, erectile issues, and depression.
January 2024 in “Polski Merkuriusz Lekarski” Pica disorder in central Iraq is mainly found in females and is linked to low iron levels; treatment with iron improves most patients.
365 citations,
November 2018 in “Journal of Allergy and Clinical Immunology” People with atopic dermatitis have different skin bacteria, and targeting these bacteria might help treat the condition.