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GlossaryCXCL12 (Stromal cell-derived factor 1)

signaling protein involved in immune response and tissue repair

CXCL12, also known as Stromal cell-derived factor 1 (SDF-1), is a protein that plays a crucial role in the body's immune response and tissue repair. It acts as a signaling molecule, attracting cells to areas where they are needed, such as sites of injury or inflammation. This protein is also important in the development and maintenance of various tissues, including hair follicles, and has been studied for its potential role in conditions like alopecia.

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research Effect of Porcine Acellular Dermal Matrix on the Expression of Stromal Cell-Derived Factor-1 and Wnt3a/β-Catenin Signaling Pathway in Mice Hair Follicle Regeneration

February 2019 in “Chin J Injury Repair and Wound Healing(Electronic Edition)”

Porcine acellular dermal matrix helps hair growth by boosting specific proteins and signals.

research LL-37 Stimulates the Functions of Adipose-Derived Stromal/Stem Cells via Early Growth Response 1 and the MAPK Pathway

53 citations, April 2016 in “Stem cell research & therapy”

LL-37 helps stem cells grow and move, aiding tissue regeneration and hair growth.

Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

research Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin

43 citations, December 2013 in “Stem Cells”

Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.

iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration

19 citations, December 2016 in “PLOS ONE”

Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.

research The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

57 citations, April 2009 in “Differentiation”

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

research Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review

26 citations, July 2021 in “Frontiers in Cell and Developmental Biology”

The review suggests that a special cell-derived treatment shows promise for various skin conditions and hair growth but needs more research for confirmation.

research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration

220 citations, March 2020 in “Advanced functional materials”

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

research Conditioned Media Derived from Mesenchymal Stem Cell Cultures: The Next Generation for Regenerative Medicine

88 citations, January 2019 in “Journal of Tissue Engineering and Regenerative Medicine”

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

research Novel Therapeutic Approaches in Utilizing Platelet Lysate in Regenerative Medicine: Are We Ready for Clinical Use?

51 citations, March 2019 in “Journal of cellular physiology”

Platelet lysate is a promising, cost-effective option for regenerative medicine with potential clinical applications.

Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

research Concentrated Conditioned Medium-Loaded Silk Nanofiber Hydrogels with Sustained Release of Bioactive Factors to Improve Skin Regeneration

5 citations, September 2019 in “ACS Applied Bio Materials”

The hydrogel with bioactive factors improves skin healing and regeneration.

research Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

271 citations, May 2019 in “Cells”

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

research Activin B Promotes BMSC-Mediated Cutaneous Wound Healing by Regulating Cell Migration via the JNK-ERK Signaling Pathway

45 citations, April 2013 in “Cell Transplantation”

Activin B improves wound healing and hair growth by helping stem cells move using certain cell signals.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations, October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

research Role of Stem Cells in Skin Maintenance, Regeneration, and Repair: Focus on Epidermis and Pilosebaceous Units

September 2013 in “Experimental Dermatology”

The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.

research Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

773 citations, August 2017 in “International Journal of Molecular Sciences”

The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.

research Injectable Silk Nanofiber Hydrogels as Stem Cell Carriers to Accelerate Wound Healing

15 citations, January 2021 in “Journal of Materials Chemistry B”

Silk nanofiber hydrogels help stem cells heal wounds faster and improve skin regeneration.

Adipose Mesenchymal Stem Cells Combined with Platelet-Rich Plasma Accelerate Diabetic Wound Healing by Modulating the Notch Pathway

research Adipose Mesenchymal Stem Cells Combined with Platelet-Rich Plasma Accelerate Diabetic Wound Healing by Modulating the Notch Pathway

39 citations, July 2021 in “Stem Cell Research & Therapy”

Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

research What Does the Concept of the Stem Cell Niche Really Mean Today?

163 citations, March 2012 in “BMC biology”

Stem cell niches support, regulate, and coordinate stem cell functions.

research Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

8 citations, October 2022 in “Regenerative Therapy”

New regenerative treatments for hair loss show promise but need more research for confirmation.

research Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review

2 citations, October 2022 in “Journal of Biomedical Science”

Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.

research Hopes and Limits of Adipose-Derived Stem Cells and Mesenchymal Stem Cells in Wound Healing

263 citations, February 2020 in “International journal of molecular sciences”

ADSCs help in wound healing and skin regeneration but need more research for full understanding.

research Scarless Wound Healing: Finding the Right Cells and Signals

132 citations, June 2016 in “Cell and Tissue Research”

The right cells and signals can potentially lead to scarless wound healing, with a mix of natural and external wound healing controllers possibly being the best way to achieve this.

research Hair Follicle Dermal Cells Support Expansion of Murine and Human Embryonic and Induced Pluripotent Stem Cells and Promote Hematopoiesis in Mouse Cultures

3 citations, August 2018 in “Stem cells international”

Hair follicle cells help maintain and support stem cells and blood cell formation.

research Orchestration of Mesenchymal Stem/Stromal Cells and Inflammation During Wound Healing

July 2023 in “Stem Cells Translational Medicine”

Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.