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Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Some medicinal plants can help heal wounds and may lead to new treatments.

Myrtle has various health benefits and potential for medicine development.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

The document concludes that a better understanding of cell changes during wound healing could improve treatments for chronic wounds and other conditions.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Alopecia is a key indicator of thallium poisoning.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.