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Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.

TGase 3 helps build hair structure by forming strong bonds between proteins.

Thyroid disease can cause skin, hair, and nail problems, and treating the thyroid condition often improves these symptoms.

Metallothionein likely helps in cell growth and development in wool follicles of fetal sheep.

Hair matrix cysts are rare skin nodules with unique features, often needing surgical removal.

Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.

A man had a large, rare cyst in his mouth removed after 10 years, which fixed his swallowing and breathing problems.

Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.

Involucrin gene expression is controlled by specific proteins and signaling pathways.

SDF-1/CXCL12 and its receptor CXCR4 are crucial for melanocyte movement in mouse hair follicles.

Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.

Knocking out certain genes in mice helps understand skin and hair growth problems.

Mice with too much Claudin-6 have skin barrier problems and abnormal hair growth.

The project created a standardized system for classifying skin lesions in lab rats and mice.

The KRTAP11-1 gene promoter is crucial for specific expression in sheep wool cortex.

Intermediate filaments are crucial for cell differentiation and stem cell function.

Coconut seed extract may effectively treat scabies in rabbits by killing mites and reducing inflammation.

The chapter explains common scalp conditions, including infections, infestations, and tumors.

A 37-year-old male with severe skin and internal issues has a rare inherited skin condition called dystrophic epidermolysis bullosa.

C/EBPalpha and C/EBPbeta are crucial for normal skin and oil gland cell development in adult mice.

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

Enlarged sweat gland ducts may indicate scarring hair loss.

Electrospun matrices help regenerate skin and hair follicles using PCL and collagen scaffolds.

Skin and hair renewal is maintained by both fast and slow cycling stem cells, with hair regrowth primarily driven by specific stem cells in the hair follicle bulge. These cells can also help heal wounds and potentially treat hair loss.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

The Megsin-Cre transgene is a new tool for genetic manipulation in the skin and upper digestive tract.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

T cells and bacteria in the gut and skin help maintain health and protect against disease.

Mohs micrographic surgery is effective for early-stage non-melanoma skin cancers on the lips, with basal cell carcinoma more common on the upper cutaneous lip and squamous cell carcinoma more common on the lower vermilion lip.

Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.