86 citations
,
December 2001 in “Experimental dermatology” This review classifies mutant mice with hair abnormalities into six categories, providing an annotated table that serves as a reference for understanding the molecular controls of hair growth.
85 citations
,
August 2018 in “Psychological Medicine” This study reported that women with PCOS had higher levels of depression, anxiety, and perceived stress compared to those without PCOS, with stress potentially mediating these associations.
84 citations
,
October 2014 in “PLoS Genetics” This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.
80 citations
,
June 2002 in “Molecular Biology of the Cell” This study found that type II keratins in proliferating epithelial tissues are phosphorylated at a conserved motif during mitosis and stress, impacting keratin solubilization and reorganization.
79 citations
,
December 2017 in “Cosmetics” This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.
76 citations
,
April 2013 in “PLoS ONE” The researchers reported that reactive oxygen species regulate the stress-induced SP-Mast cell pathway, which might support using antioxidants to treat stress-related hair loss.
75 citations
,
August 2003 in “International journal of cosmetic surgery and aesthetic dermatology” This study found that low level laser therapy with a HairMax LaserComb improved hair counts and tensile strength in patients with androgenetic alopecia, particularly in males and vertex areas.
74 citations
,
January 2013 in “Expert Opinion on Biological Therapy” This review discusses recent advances in hair follicle biology, regeneration, and tissue engineering, highlighting emerging therapeutic opportunities, and reports no new experimental results.
73 citations
,
October 2013 in “International Journal of Cosmetic Science” This review examines the chemical composition and potential health risks of hair straighteners, but it reports no new findings and emphasizes the importance of understanding hair fibre structure for safe use.
73 citations
,
January 2013 in “European journal of dermatology/EJD. European journal of dermatology” This review examines current research on antioxidants in autoimmune skin diseases like alopecia areata and vitiligo, concluding with suggestions for future studies and treatment possibilities without reporting new clinical results.
72 citations
,
July 2003 in “Journal of cosmetic dermatology” This review discusses the psychological importance of hair and explores how various hair cosmetics can affect hair health, emphasizing that certain products can lead to acute hair problems when repeatedly altering the natural style.
70 citations
,
March 2008 in “Mechanisms of Ageing and Development” This review discusses genome maintenance mechanisms critical for preventing age-related diseases by preserving stem and progenitor cell potential, but reports no new empirical findings.
67 citations
,
August 2013 in “International Journal of Cosmetic Science” This review discusses the role of oxidative stress in hair greying and suggests that understanding melanocyte susceptibility at different follicular locations may help develop therapies for preventing and reversing the process; it reports no new experimental results.
65 citations
,
May 2010 in “Current Women's Health Reviews” This review discusses oxidative stress's role in polycystic ovary syndrome and examines various biomarkers to understand its impact on the disorder's pathogenesis, but reports no new clinical results.
63 citations
,
January 1992 in “Experimental Neurology” This study in neonatal chicks reported that intense sound exposure severely impaired auditory function, but function returned to near normal within 3 days, primarily due to non-hair-cell mechanisms.
62 citations
,
July 2013 in “American Journal of Clinical Dermatology” This study found that alopecia areata patients had higher oxidative stress and lipid peroxidation levels than healthy controls, suggesting potential involvement in the disease's pathogenesis.
61 citations
,
November 2020 in “Molecules” This review examines the design strategies for creating conductive hydrogels with adjustable properties for various biomedical applications, highlighting their potential for supporting cell growth, wound healing, drug delivery, tissue regeneration, and biosensing.
59 citations
,
November 2015 in “International Journal of Cosmetic Science” This review considers oxidative stress effects on hair aging and emphasizes the need for dermatologists to recognize and treat factors affecting scalp and hair health, but it provides no new clinical findings.
58 citations
,
October 2016 in “Journal of Investigative Dermatology” This study found that activating Nrf2 in human hair follicles significantly reduced oxidative stress, lipid peroxidation, and protected against hair growth inhibition, suggesting a protective role for Nrf2 against redox insult in this context.
57 citations
,
May 2014 in “Molecular Phylogenetics and Evolution” This study utilized a sequence-structure alignment approach to improve the characterization of Class A Rhodopsin GPCR superfamily, including orphan and unclassified receptors, through evolutionary analysis.
55 citations
,
March 2007 in “Journal of cosmetic dermatology” This review discusses the historical development of hair straightening products for Afro-ethnic hair and reports no new research findings.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
52 citations
,
September 2020 in “Cell Death and Disease” This study found that impaired autophagy plays a role in sonic hedgehog pathway-induced endometrial fibrosis, suggesting it as a potential target for treating intrauterine adhesion.
52 citations
,
May 2015 in “Cytotherapy” This study found that human mesenchymal stromal cells derived from hair follicle dermal sheath showed promising growth and wound-healing properties in vitro and in diabetic mice, suggesting potential for therapeutic use.
52 citations
,
February 2005 in “Biopolymers” In this study, chemical treatments during permanent hair straightening were found to randomize proteins in the cortex, aiding in the reconnection of disulfide bonds during oxidation.
51 citations
,
October 2024 in “Pharmaceutics” This review highlights the potential of permeation enhancers to improve the delivery of active ingredients across the skin, optimizing therapeutic outcomes despite challenges posed by individual variability and environmental factors, according to the authors' analysis of current understanding and applications in skincare and transdermal therapies.
51 citations
,
December 2017 in “Skin Appendage Disorders” This review examines the literature on autoimmune hair loss disorders, highlighting the collapse of immune privilege and the potential role of neurogenic stress in this process, but reports no new clinical results.
51 citations
,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.
50 citations
,
March 2001 in “Clinics in dermatology” This paper reviews the complex anatomy and development of human hair and emphasizes the need to understand these processes for interpreting drug incorporation into hair, with no new clinical results reported.
49 citations
,
July 2021 in “Nutrients” This review explores lifestyle modifications for women with polycystic ovary syndrome, discussing dietary, physical, and supplementation strategies, but reports no new clinical results.