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This study found that serine 44 in the N-terminal head domain of keratin 17 is phosphorylated in response to various stimuli affecting skin keratinocyte growth, linking K17 up-regulation with growth and stress responses in skin epithelium.

This study observed that inflammatory stimuli significantly altered gene expression in rat theca-interstitial cells, affecting pathways related to growth and androgen production, which are central features of polycystic ovary syndrome.

This study found that capped mesoporous silica nanoparticles conjugated with antibodies selectively released a dye when exposed to finasteride, with low detection limits and stable performance even after storage.

This review introduces a framework to integrate bioinspired conductive materials and advanced 3D/4D printing in regenerative medicine for dynamic, responsive tissue regeneration, emphasizing the potential of smart scaffolds to adapt to physiological cues.

This review highlights cellulose-based materials' potential in skin disease treatments, emphasizing their smart, responsive design for various conditions, with insights into their roles in wound healing, infection prevention, and wearable monitoring.

In this review, researchers explored thermo-responsive polymers and their applications in nanomedicine, highlighting their role in targeted drug delivery, gene therapy, and imaging, enabled by their temperature-sensitive phase transitions to ensure localized therapeutic action and minimize damage to healthy tissues.

This review examines advancements in "smart" hydrogel dressings for complex wound healing, highlighting innovations in materials that provide multifunctionality, such as responsive drug delivery and regenerative capabilities. The study also addresses potential challenges in clinical application, like manufacturing and regulatory hurdles.

This review discusses recent advancements in responsive-hydrogel dressings for diabetic wound healing, highlighting their design, responsiveness, and degradation behavior, and evaluating their potential advantages and limitations in clinical applications.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

This study found that overexpression of the transcription factor Tcf3 accelerates keratinocyte migration and skin wound healing in mice, highlighting its potential as a therapeutic target for wound repair.

This review examined photothermal hydrogels, biomedically innovative materials responsive to near-infrared stimulation, which hold promise for enhancing infection control and tissue regeneration. The authors highlighted their unique properties, construction methods, and potential applications while also discussing existing challenges and future research directions.

This review highlights the potential of microneedles and nanomedicine in advancing tissue regeneration, emphasizing their innovative, localized, and minimally invasive approaches as promising solutions to current challenges in treating chronic wounds and degenerative diseases.

This review discusses current strategies and materials in tissue engineering for skin regeneration, emphasizing design approaches and suggesting directions for future research; it reports no new clinical findings.

This study found that TRPA1-deficient mice exhibited normal cold sensitivity but had decreased mechanical response in nociceptors, suggesting TRPA1's role in mechanotransduction.

In this study, researchers observed that knocking out KCNQ3 in mice increased firing frequencies in response to stimuli, particularly at slow mechanical indentation velocities, indicating a role in mechanosensory neuron sensitivity.

This review highlights how nanotechnology enhances CRISPR-Cas9's potential for cancer treatment by improving delivery and stability, addressing key challenges like immunogenicity and delivery inefficiencies, and discusses recent advancements in stimuli-responsive nanoplatforms for precise genome editing.

This review discusses the strategies and potential of CRISPR delivery for gene therapy, highlighting the challenges and innovative use of stimuli-responsive nanocarriers, but reports no new experimental results.

This study found that a 3D wound model, the 3DWoundSE, showed improved responsiveness to injury and cytotoxic stimuli compared to an intact 3D skin equivalent, offering a reproducible and ethical alternative to animal models for early wound response assessment in dermatological research and drug development.

This chapter discusses various skin functions and structures involved in protection, immune response, and homeostasis, but it reports no new research findings.

In this review, the authors discuss recent advancements in underwater adhesion technologies, specifically highlighting mussel-inspired catechol-based adhesives, which offer strong underwater bonding through various interfacial interactions and the influence of dopamine-modified polymeric tissue adhesives.

This review highlights the promise of non-viral gene delivery systems, particularly genosomes, over traditional viral vectors due to enhanced safety and efficiency in therapeutic nucleic acid delivery for genetic diseases like cystic fibrosis and malignancies.

This study reported that 4D-printed, aliphatic polycarbonate-based scaffolds supported adipose tissue engineering by allowing adipocyte infiltration and neovascularization in vivo, indicating potential for effective adipose tissue repair.

This review discusses nanoparticle systems for cancer treatment and reports no new clinical results; the authors emphasize their potential to reduce systemic toxicity and call for further development.

In this study, researchers developed iron-curcumin-coordinated nanoparticles to enhance curcumin's bioavailability and therapeutic effects, finding that these nanoparticles accelerate wound healing in diabetic mice by reducing inflammation and oxidative stress more effectively than free curcumin.

This review discusses nanotechnology-based therapies for chronic wound healing and highlights their potential, but it reports no new clinical results.

This review article summarizes recent advancements in biomimetic scaffolds, highlighting their promise in tissue engineering and personalized medicine, particularly for skin and musculoskeletal system regeneration, while emphasizing the need for more extensive research to ensure their safety for human use.

This review analyzes the role of silver nanoparticles in wound healing, highlighting their antimicrobial, anti-inflammatory, and tissue-regenerating properties, and emphasizes the need for further research to optimize formulations and ensure safety.

This review outlines the design and engineering of multifunctional hydrogels, emphasizing their evolving biomedical applications, notably in controlled drug delivery, tissue support, and disease management, and discusses their potential for clinical translation.

This review highlights recent advancements in nanotechnology-based approaches for treating androgenetic alopecia, focusing on enhancing drug delivery to hair follicles, controlled release, and follicular microenvironment modulation, while addressing safety, manufacturing, and regulatory challenges for clinical application.

This review outlines recent progress in CRISPR/Cas9 genome editing, discussing its structure, mechanisms, and the use of genetic, chemical, and physical strategies to enhance precision and reduce off-target effects despite some persistent challenges for clinical application.