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This review discusses the role of mechanical forces in skin homeostasis and disease development, including their impact on conditions like keloids, androgenetic alopecia, and acral melanoma, and reports no clinical results; the authors propose modifying these forces as a potential therapeutic strategy.

In this study, researchers demonstrated that the expression of the oncogene SmoM2 leads to basal cell carcinoma in the ear epidermis of mice but not in the back skin, with differences in susceptibility linked to the composition of the extracellular matrix.

This study found that in wound-induced hair neogenesis, African spiny mice and laboratory mice exhibit different morphogenetic field formation patterns related to tissue stiffness, suggesting evolutionary developmental biology advantages.

This study showed that chemical and mechanical treatments significantly alter the nanoscale surface properties of hair, affecting its roughness, mechanical stiffness, adhesion, and surface potential.

This study found that early-onset androgenetic alopecia, especially with a vertex pattern, may be an independent risk factor for cardiovascular disease and metabolic syndrome in men.

This review outlines the role of mechanical forces in the development of sensory organs like eyes and ears, emphasizing insights from recent animal studies and microfabricated organoid systems; it presents no new experimental results.

This study found that (-)-blebbistatin significantly inhibited liver fibrosis in mouse models by reducing tissue stiffness and myofibroblast activation, indicating potential for developing broad-spectrum antifibrotic drugs.

This study investigated the effects of wool-derived hydrolysed keratin peptides on relaxed textured hair and found that mid- and high-molecular weight peptides improved mechanical strength and reduced breakage in different humidity conditions.

This study's simulations suggest that biomechanical factors, like follicle geometry and tissue stiffness, are likely significant in hair fiber protrusion, providing a framework for future experimental validation.

This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.

This study found that multiparametric ultrasound effectively detects real-time scalp changes caused by vasoconstrictive cosmetic agents, demonstrating its potential as a non-invasive tool for evaluating trichological treatments.

This animal study observed that dihydrotestosterone increased arterial stiffness and decreased estrogen receptor expression in female mice, potentially impacting cardiovascular health in contexts of androgen use.

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

This study found that testosterone contributed to increased arterial stiffness and cardiovascular damage in female mice, linked with decreased estrogen receptor expression, and suggests implications for women with polycystic ovarian syndrome or those taking testosterone.

This study found that inducing miR-205 reduces actin contractility and stiffness in hair follicle stem cells and progenitors, stimulating hair regeneration in both young and old mice.

This study found that manipulating both gene expression and matrix stiffness in mice can alter hair regeneration after skin wounding, highlighting key factors in regenerative biology.

This study explores torsional measurements of single hair fibers to differentiate the effects of cosmetic treatments on hair structure, highlighting their potential to reveal shear stiffness changes related to cuticle damage.

In this study, FN-based fiber scaffolds designed using Rotary Jet-Spinning were shown to enhance wound healing and reduce scar formation in a mouse model, suggesting potential for regenerating healthy skin structure.

African spiny mice can regenerate skin and hair after wounds due to specific tissue mechanics.

This study investigates the potential link between atrial fibrillation and circulating aldosterone levels related to cardiac fibrosis in patients with hypertension.

This study identified a unique concentric double-layered structure in both Japanese and Caucasian SHINAYAKA hair, associated with improved flexibility and elasticity, and developed a succinic acid treatment to enhance these properties.

In this study, researchers observed that inhibiting myosin light chain kinase in hair cells reduced stiffness and oscillation in bullfrog hair bundles and increased hearing thresholds in mice.

This study characterized the stress-strain properties of the human scalp and found that its stiffness increases significantly with load, providing valuable insights for planning scalp surgery procedures.

This study introduces a new test using a pendulum device to assess the bending stiffness of hair fibers, which can evaluate the effects of different hair treatments.

This study found that the keratin matrix in mammalian hard α-keratins is crucial for maintaining stiffness in water by controlling intermediate filament hydration.

This study found that a single injection of Platelet Rich Stroma improved knee function and reduced pain and stiffness in patients with knee osteoarthritis over twelve months.

This case report describes a 10-year-old girl with lamellar ichthyosis who showed marked improvement in scaling and skin stiffness after six weeks of treatment with emollient and supportive therapy.

This case report highlights a female patient with familial partial lipodystrophy who showed significant improvement in liver stiffness after starting leptin replacement therapy.

This study found that keratin intermediate filaments in the hair of GAN patients are altered, showing decreased diffraction signals and increased stiffness, strength, and extensibility.

In this study, AFM-based indentation was used to assess mechanical properties of murine skin wounds at two healing stages, revealing that early wounds exhibit stiffer hyperproliferative epithelium compared to granulation tissue, and highlighting significant influences of surface roughness on tissue stiffness measurements.