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Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Finasteride exposure harms tadpole reproduction and hormone balance.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

Glioblastoma cells can make androgens, which might help the tumor grow.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Sebocytes play a key role in controlling androgen levels in human skin.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Testosterone may slow down wound healing and increase inflammation.

DHT, a testosterone byproduct, causes male pattern baldness.

Certain drugs that block specific enzymes can help treat prostate diseases.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Quercetin may help with PCOS symptoms, but more research is needed.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.