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Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

SHBG may be a useful early indicator and treatment target for PCOS.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Adrenal disorders can cause lasting brain and behavior issues in children.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

A male with aromatase deficiency improved bone health with estradiol treatment.

Measuring reproductive hormones in brown bear hair could help identify their sex and reproductive state, but better collection methods or lab techniques are needed.

Curcumin may improve blood sugar levels and cholesterol in people with PCOS, but more research is needed.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Finasteride may improve prostate cancer treatment outcomes.