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Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Women with type 1 diabetes often have polycystic ovary syndrome and excess male hormones, which are frequently undiagnosed.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

Quercetin may help with PCOS symptoms, but more research is needed.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Natural molecules like inositols, resveratrol, vitamins, and omega-3 fatty acids may help manage Polycystic Ovary Syndrome (PCOS), but their effects vary and need more exploration.

Most dogs with alopecia had higher than normal levels of certain hormones, but hair loss might not always be linked to these hormone changes.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Early onset baldness in men may indicate a condition similar to PCOS, linked to heart disease, diabetes, and prostate issues.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.