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Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Method detects finasteride in plasma and semen with high sensitivity and accuracy.

Finasteride effectively treats male hair loss, improving growth and density.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.

Desolvation of finasteride depends on environment and technique.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Chemicals from the plant Dicerocaryum senecioides were found to safely speed up and increase hair growth in mice.

Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.

Adiantum capillus extract reduces pain and swelling in animals.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Tributyltin exposure causes sex changes, sterilization, and decline in the snail Ocinebrina aciculata, risking its extinction.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

Plant cell culture is a promising method for creating sustainable and high-quality cosmetic ingredients.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Finasteride temporarily lowers male rat fertility without affecting libido.

Suppressing certain hormones might help prevent prostate cancer.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.