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Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Hormone treatment for transgender patients may not need to be stopped before surgery, but more research is needed, especially on estrogen.

Key genes are crucial for Drosophila wing development and could be insecticide targets.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

DHT, a testosterone byproduct, causes male pattern baldness.

Androgen conjugates might be better indicators of skin sensitivity to hormones in women with excessive hair growth.

Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

The drug enzalutamide may reduce the ability of the virus causing COVID-19 to enter lung cells.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Flutamide reduces hair growth better but has more side effects.

A boy with severe Vitamin D-resistant rickets did not respond to treatment and lacked a common symptom, suggesting a need for alternative treatments.

Red Ginseng Extract may help human hair grow by activating growth pathways and blocking negative effects of certain hormones.

The combination of cyproterone acetate and testosterone enanthate is highly effective in preventing sperm production and could be a good reversible male contraceptive.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Long-term finasteride use doesn't change bone density or metabolism.

Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.

5α-reductase inhibitors, like finasteride and dutasteride, effectively treat BPH, male baldness, and hirsutism, with potential for acne and prostate cancer prevention.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Rosemary extracts with carnosic acid and carnosol can reduce the harmfulness of Staphylococcus aureus without stopping its growth.

Finasteride for hair loss may cause long-lasting side effects like impotence and low libido, but trials lack proper safety reporting.