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The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Diagnosing PCOS in teenagers is challenging and should use strict criteria to avoid misdiagnosis and unnecessary worry.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

PrEP for HIV is less effective in transgender women mainly due to low adherence to the treatment.

Androgens can both increase and decrease hair growth in different parts of the body.

Pregnancy can cause various skin changes and diseases, with PUPPP being the most common skin condition specific to pregnancy.

Hormone therapy for trans individuals is effective and generally safe in the short term.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Dermoscopy helps diagnose and manage alopecia areata by showing specific hair changes.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

Oral antiandrogens effectively treat female hair loss, with better results in higher hair loss grades.

Fibrinogen/LDL apheresis may improve speech perception in sudden hearing loss, especially for those with high fibrinogen and LDL levels.

Hair loss needs more research for better treatments.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Mostly postmenopausal Caucasian women get Frontal Fibrosing Alopecia, which often includes eyebrow loss and has limited treatment success.