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Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

5 alpha-reductase inhibitors like finasteride may lower prostate cancer risk and improve cancer screening.

Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.

Hair loss in men may be caused by inflammation triggered by hormones, and treatments reducing inflammation could potentially promote hair growth.

Some people experience lasting sexual, psychological, and sleep problems after using finasteride or SSRI antidepressants, possibly due to similar underlying causes.

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

Testosterone can help premenopausal and postmenopausal women with low sexual desire, but its long-term safety is unclear and it's not widely approved for this use.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

Androgens like testosterone may help treat traumatic brain injury by reducing mitochondrial stress and inflammation.

Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.

Hormones and stretching both needed for nipple area skin growth in mice.

Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.

Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.

Metformin lowers prolactin in women without PCOS but not in those with PCOS, where it reduces other hormones instead.

No link found between specific genes and female pattern hair loss.

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

A new compound effectively inhibits human 5α-reductase 1.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Removing vitamin D and calcium receptors in mice skin cells slows down skin wound healing.

PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Testosterone may slow down wound healing and increase inflammation.