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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Genetic analysis of rabbits identified key genes for traits like coat color, body size, and fertility.

Antiandrogens help treat hormone-related conditions in both men and women.

Baldness in men with prostate cancer is linked to higher levels of certain sex hormones, but chest hair density is not.

The study concludes that a genetic mutation in TFM mice leads to reduced androgen receptor activity, affecting the body's response to male hormones.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Vitamin D receptor is crucial for bone health and mineral metabolism.

Androgens, male hormones, play a role in both men and women's health, and testosterone therapy can help women with low levels, but it's not suitable for pregnant or lactating women, or those with certain conditions.

A patient with multiple sclerosis developed skin reactions after Daclizumab treatment, requiring more data on the drug's effects.

Androgen affects oil production and hair growth in the skin.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.

Scientists found new nonsteroidal compounds that can act like natural male hormones and might help treat male fertility and hormone issues.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Cimicifuga racemosa extract may help prevent and treat prostate issues by inhibiting 5α-reductase.

Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Blocking DHT production more strongly may help control advanced prostate cancer and improve quality of life.

Riboflavin 5′-phosphate (FMN) shows potential for treating androgen-related conditions but may be limited in treating prostate cancer.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

A transwoman developed a brain tumor after nine years of hormone therapy, suggesting a possible link between the treatment and tumor development.

A new gene variant causes glucocorticoid resistance in a mother and son.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.