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Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Spironolactone harms fish reproduction and is more potent in fish than invertebrates, needing environmental monitoring.

The document concludes that diagnosing PCOS requires a thorough approach, considering various symptoms and risks, and calls for improved methods to identify PCOS types and prevent diabetes.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

Polycystic Ovary Syndrome (PCOS) is common in women with conditions like anovulation, hirsutism, hair loss, and type 2 diabetes, and it can lead to health risks like heart disease, obesity, insulin resistance, and depression. Non-Classic Congenital Adrenal Hyperplasia (NC-CAH) is also discussed.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

The study found that the hair loss condition in Cesky Fousek dogs is influenced by multiple genes affecting skin and muscle structure, fat metabolism, and immunity.

Nonclassic adrenal hyperplasia is a genetic condition that can cause early puberty and fertility problems, treated with specific steroids.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

DHT affects testicular development and regulates spermatogenesis in some fish.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

Mice without active or present vitamin D receptors maintain normal blood sugar control and islet gene expression when calcium levels are normal.

Finasteride reduces hair growth and is safe for women with excessive hair.

Telogen is an active phase with important biological processes, not a resting phase.

Certain genetic variations are linked to increased androgen levels in PCOS, but more research is needed to understand these connections fully.

Understanding glycans and enzymes that alter them is key to controlling hair growth.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

Dutasteride may help reduce brain plaque linked to Alzheimer's by affecting cell energy structures and waste removal.

Taking oral testosterone with or without dutasteride increases testosterone levels and could be an effective treatment for low testosterone.

Androstenedione is better than testosterone for diagnosing PCOS in Indian women.

PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.