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Certain mutations in the H6PD gene cause Cortisone Reductase Deficiency by affecting hormone production.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

A new compound effectively inhibits human 5α-reductase 1.

A boy with a rare skin condition and kidney disease improved with cyclosporine after steroids failed, suggesting a new treatment approach.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

A 24-year-old woman had a rare ovarian tumor that caused male-pattern hair growth and was hard to diagnose and treat.

A young woman had a rare, aggressive ovarian tumor that was hard to diagnose and treat, leading to disease progression despite treatment.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Alopecia in captive rhesus macaques is affected by season, sex, age, housing, and stress, with complex links between stress hormones and hair loss.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

A woman with severe angioedema improved significantly after treatment with rituximab.

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.

Athletes use steroids to enhance performance despite health risks and legal issues, and education on their dangers is needed.