research Antiandrogen Therapy in Dermatology
Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.
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research Review of the Effects of 17α-Estradiol in Humans: A Less Feminizing Estrogen with Neuroprotective Potential
17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.
research Menstrual Disorders: Comprehensive Overview and Diagnostic Approaches
The document says menstruation is important for women's health, discusses menstrual disorders, and suggests personalized treatment options.
research Immunological Aspects and Gender Bias During Respiratory Viral Infections Including Novel Coronavirus Disease-19 (COVID-19): A Scoping Review
Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.
research Controversies in Plastic Surgery: Suction-Assisted Lipectomy and the hCG Protocol for Obesity Treatment
The document concludes that the hCG protocol may help in obesity treatment and could be scientifically justified, but more research is needed.
research In Vivo Uptake and Metabolism of Testosterone by the Skin and Other Tissues of the Rat
Rat skin takes up and processes testosterone differently than other organs, with testosterone being more important for the skin than its metabolite 5α-DHT.
research Serum Ferritin and Vitamin D Levels Should Be Evaluated in Patients With Diffuse Hair Loss Prior to Treatment
Check and treat low iron and vitamin D levels in people with hair loss.
research Androgens and the Menopause
Testosterone replacement may help postmenopausal women with sexual function and bone density, but suitable treatments are limited.
research Androgen Excess: A Hallmark of Polycystic Ovary Syndrome
Excess androgens may cause PCOS, not just be a symptom.
research Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update
The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.
research AKR1D1 Regulates Glucocorticoid Availability and Glucocorticoid Receptor Activation in Human Hepatoma Cells
AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.
research Urinary Steroids in Men with Male-Pattern Alopecia
Men with male-pattern baldness have higher levels of certain testosterone metabolites and may have more active androgen metabolism.
research Neuroactive Steroids and Ethanol Exposure: Relevance to Ethanol Sensitivity and Alcohol Use Disorders Risk
Neuroactive steroids may affect the risk and treatment of alcohol use disorders.
research Steroidogenesis of the Testis: New Genes and Pathways
New genes and pathways are important for testosterone production and male sexual development.
research Effect of Finasteride on Behavioral Arousal and Somatosensory Evoked Potentials in Fetal Sheep
Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.
research Testicular Steroidogenesis: Production and Regulation of Testosterone and Dihydrotestosterone
Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
research Early Postnatal Allopregnanolone Levels Alteration and Adult Behavioral Disruption in Rats: Implications for Drug Abuse
Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
research Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role
Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.
research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
research A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer
Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.
research Expression of Steroidogenic Enzymes in Human Sebaceous Glands
Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.
research Prostaglandin Metabolism in Human Hair Follicle
Human hair follicles can make and process prostaglandins, which may affect hair growth.
research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD
Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
research A Rapid Method for Obtaining Finasteride, a 5α-Reductase Inhibitor, from Commercial Tablets
Quickly get finasteride from tablets using easy methods.
research Polymorphisms in Androgen and Estrogen Receptor Genes: Effects on Male Aging
Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.
research Genetic Variations Associated With Response to Dutasteride in the Treatment of Male Subjects With Androgenetic Alopecia
Genetic variations affect dutasteride treatment response for male pattern hair loss.
research How Does Altered Metabolism Lead to Seizure Control? Partially Filling the Knowledge Gap
Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.
research The Effects of Oral 5-Alpha Reductase Inhibitors on Penile Intracavernosal Pressures and Penile Morphology in a Rat Model
Oral finasteride and dutasteride may negatively affect erectile function in rats.
research Neurosteroids on the Epilepsy Chessboard: Keeping Seizures in Check
Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.
research In This Issue
Alexander the Great's engineers built a causeway using a natural sand bridge, some tiger moths avoid bats by mimicking toxic relatives' sounds, early metabolism and RNA enzymes support the ancient RNA world theory, and vitamin D is crucial for hair growth and its absence can cause baldness.