research Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents
Long-term use of azole antifungals can cause hair loss, hormonal imbalances, and severe skin reactions.
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research The Mechanisms and Management of Age-Related Oxidative Stress in Male Hypogonadism Associated with Non-Communicable Chronic Disease
Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.
research Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome
Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.
research Involvement of Neurosteroids in the Control of Hypothalamic-Pituitary-Adrenal Axis Activity in Pregnant Sheep Under Basal and Stressful Conditions
Neurosteroids play a key role in controlling the brain-adrenal gland activity in pregnant sheep, both in normal and stressful situations.
research Recent Advances in Understanding of the Etiopathogenesis, Diagnosis, and Management of Hair Loss Diseases
New understanding and treatments for hair loss are improving, but more research is needed.
research Dihydrotestosterone Induces Arterial Stiffening in Female Mice
Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.
research Hormonal Treatment of Transgender Women with Oral Estradiol
Oral estradiol works for many transgender women but needs personalized dosing and monitoring.
research Phytochemicals With Anti 5-Alpha-Reductase Activity: A Prospective For Prostate Cancer Treatment
Plant-based compounds might be a promising alternative for prostate cancer treatment with fewer side effects.
research Finasteride Delays Atherosclerosis Progression in Mice and Is Associated With a Reduction in Plasma Cholesterol in Men
Finasteride may lower cholesterol and slow heart disease progression.
research Lipolytic Agents for Submental Fat Reduction: Review
Deoxycholic acid is FDA-approved for reducing submental fat, but its mechanisms are not fully understood.
research Identification of Potential Cytochrome P450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design
Potential new drugs for treating PCOS were identified.
research Ideal JAK Inhibitor for Alopecia Areata: Baricitinib, Tofacitinib, Ritlecitinib, or Ifidancitinib - Revisiting the Immunomechanisms of the JAK Pathway
No single ideal JAK inhibitor for alopecia areata has been determined; JAK3 inhibitors may be promising with fewer side effects.
research Endocrinological Assessment in Transgender Individuals
The document concludes that personalized hormonal treatments are important for transgender individuals and more research is needed for non-binary treatments.
research Autophagy Protects Murine Preputial Glands Against Premature Aging and Controls Their Sebum Phospholipid and Pheromone Profile
Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.
research Steroidogenesis Inhibitors Alter But Do Not Eliminate Androgen Synthesis Mechanisms During Progression to Castration-Resistance in LNCaP Prostate Xenografts
Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.
research Understanding, Recognizing, and Managing Toxicities of Targeted Anticancer Therapies
Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.
research Cutaneous Manifestations of Polycystic Ovary Syndrome
Skin problems like acne and excess hair in PCOS are common and linked to being overweight.
research Aldosterone- and Cortisol-Cosecreting Adrenal Adenoma, Ovarian Hyperthecosis, and Breast Cancer
The conclusion is that thorough investigation of hypertension and hormonal dysfunctions is important, and there may be a link between these conditions and cancer.
research Androgen Treatment of Postmenopausal Women
Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.
research Selenium and Polycystic Ovary Syndrome: Current Knowledge and Future Directions
Selenium might help with insulin resistance and cholesterol in PCOS, but more research is needed to confirm its benefits.
research The Cycle Characteristics and Outcomes of Infertile Nonclassic 21-Hydroxylase Deficiency Patients Undergoing Ovarian Stimulation for In Vitro Fertilization
Women with nonclassic 21-hydroxylase deficiency can have successful pregnancies through IVF, with certain factors affecting their chances.
research Azasteroids as Inhibitors of Testosterone 5α-Reductase in Mammalian Skin
Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.
research Epitestosterone: Regulatory Roles in Androgen-Dependent Processes
Epitestosterone may counteract testosterone's effects and has roles in body processes like prostate growth and hair distribution.
research Polycystic Ovary Syndrome (PCOS): An Inflammatory, Systemic, Lifestyle Endocrinopathy
PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.
research Role of Androgens in Female-Pattern Androgenetic Alopecia, Either Alone or Associated with Other Symptoms of Hyperandrogenism
Androgens significantly affect female hair loss, and hormonal treatments may help.
research Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line
Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.
research A Humanized Mouse Model of Hereditary 1,25-Dihydroxyvitamin D–Resistant Rickets Without Alopecia
Researchers created a mouse model of a type of rickets that does not cause hair loss.
research Modeling the Pharmacodynamics of Nandrolone Doping Drug and Implications for Anti-Doping Testing
The document concludes that finasteride can reduce nandrolone detection in doping tests, suggesting frequent testing and setting metabolite level thresholds for detection.
research Body Composition Changes and Inhibition of Fat Development In Vivo Implicate Androgen in Regulation of Stem Cell Lineage Allocation
Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.
research Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism
Finasteride reduces hair growth and is safe for women with excessive hair.