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Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

Biotin is important for health, but taking extra usually doesn't help unless you're deficient.

Human skin can make serotonin and melatonin, which help protect and maintain it.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.

Ziziphus jujuba Mills may have health benefits, but more research is needed to confirm its safety and effectiveness.

New compounds may soon be tested to treat excessive hair growth in women.

Different skin cells process testosterone differently, and certain drugs can change this process, possibly helping treat acne and hair loss.

Teriflunomide effectively reduces relapses and disability in MS and has a manageable safety profile.

Finasteride breakdown products found in bile and urine, helps understand drug safety and effectiveness.

Ketoconazole increases finasteride's effectiveness and lifespan in the body.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Testosterone therapy can help postmenopausal women with low sexual desire but needs more safety research and should be used with estrogen therapy.

Testosterone therapy can help with androgen deficiency in women but should be used with caution and monitoring due to potential risks.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

Muscles can make their own androgens, which may help muscle growth.

Finasteride worsens heart damage from nandrolone decanoate but protects against cell damage.

Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.

More high-quality research is needed to recommend flavonoids and saponins for clinical use.

Drinking a lot of alcohol increases the risk of prostate cancer and can worsen the condition.

Women with PCOS have more Bifidobacterium in their gut compared to those without PCOS.