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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Imaging helps detect adrenal gland issues and monitor treatment in congenital adrenal hyperplasia, and can identify tumors affecting fertility.

Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Certain genetic changes in the LSS gene cause a rare skin and hair condition.

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

The study concluded that similar pathways regulate hair growth in dogs and mice, and these pathways are disrupted in dogs with Alopecia X, affecting stem cells and hormone metabolism.

Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.

Certain gene variations are linked to a higher risk of severe acne, suggesting a genetic influence on the condition.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

Eclipta prostrata is a medicinal plant that helps treat diseases, protects the liver and nerves, and promotes hair growth.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

BB4CMU rice bran oil may help treat hair loss and gray hair.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Acne in dark skin is influenced by environmental factors and can lead to hyperpigmentation, with various treatment options available.

Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Manipulating cell cleanup processes could help treat hair loss.