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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Genes and epigenetic changes are important in the development of Polycystic Ovary Syndrome.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

Mutations in the androgen receptor gene cause Androgen Insensitivity Syndrome, affecting sexual development.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

The vitamin D receptor has many roles in the body beyond managing calcium, affecting the immune system, hair growth, muscles, fat, bone marrow, and cancer cells.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Testosterone is crucial for development, growth, and various body functions in mammals.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

Dutasteride and finasteride affect different cell types differently.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.